Publications by authors named "J Emsley"
To optimize the identification of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected children, specimen collection and testing method are crucial considerations. Ideally, specimen collection is easy and causes minimal discomfort, and the laboratory approach is simple, accurate, and rapid. In this prospective cohort study we evaluated the accuracy of a point-of care nucleic acid device using caregiver/patient self-collected buccal swabs.
View Article and Find Full Text PDFIntroduction: The interleukin-33/interleukin-1 receptor-like-1 (IL-33/IL1RL1) signalling pathway is implicated in asthma pathogenesis, with IL1RL1 nonsynonymous genetic polymorphisms associated with disease risk. We aimed to determine these variants' effect on IL1RL1 signalling induced by different IL33 isoforms thought to be elevated in the asthmatic airway.
Method: In a project funded by GSK plc, which has developed an IL-33 receptor inhibitor for asthma treatment, human embryonic kidney 293 (HEK293) cells expressing secreted embryonic alkaline phosphatase (SEAP) driven by a nuclear factor kappa-beta (NF-κB) promoter, were transiently transfected with IL1RL1, containing one of four extracellular and Toll/interleukin 1 receptor (TIR) domain haplotypes.
Article Synopsis
- The study aimed to evaluate the relationship between social behaviors and SARS-CoV-2 test positivity in children under 18 years old during 2020-2022, using data from emergency departments.
- It found that attending social gatherings increased the chances of testing positive for SARS-CoV-2 in children aged 5-<12 years while in-person daycare/school attendance was linked to a lower risk of positivity across all age groups.
- Key findings indicated that children's risk of infection was influenced by factors like mask-wearing and exposure to infected contacts, with settings like schools promoting better public health practices, thus lowering risk.
Objective: To assess the association between Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and long-term quality of life (QoL).
Methods: Prospective cohort study with 6- and 12-months follow-up conducted in 14 Canadian institutions. Children tested for SARS-CoV-2 between August 2020 and February 2022 were eligible.
Article Synopsis
- - Rondaptivon pegol (BT200) is a modified RNA aptamer that increases levels of von Willebrand factor (VWF) in the blood by interfering with its removal by the immune system, particularly macrophages.
- - The study shows that BT200 specifically binds to a crucial part of the VWF protein (the A1 domain), which helps prevent the VWF from being cleared too quickly by liver receptors (LRP1).
- - The findings suggest that targeting pathways that clear VWF from the body may be an effective new treatment strategy for conditions like von Willebrand disease and hemophilia A.