No effect of vitamin B-12 treatment on cognitive function and depression: a randomized placebo controlled study.

Background: Associations between vitamin B-12 deficiency and impaired cognitive function and depression have been reported.

Methods: A randomized placebo controlled study including 140 individuals with an increased plasma methylmalonic acid (0.40-2.

Health technology assessment in clinical biochemistry. Methylmalonic acid: a Danish showcase.

In 1992 plasma methylmalonic acid (MMA) was introduced in Denmark for diagnosing vitamin B-12 deficiency. Now, 10 years later, we report on a health technology assessment (HTA) suggesting that the clinical usefulness of MMA is uncertain. MMA is an obvious component for measurement in the diagnosis of vitamin B-12 deficiency because MMA accumulates when there is a lack of vitamin B-12, and technologically the analysis is of high quality.

[Diagnosis of vitamin B12 deficiency--time for reflection].

Since plasma methylmalonic acid (MMA) was introduced in Denmark in 1992 both MMA and P-cobalamins have been increasingly employed to diagnose vitamin B-12 deficiency, and the consumption of vitamin B-12 has been almost doubled during the same period. The controversy about diagnosing vitamin B-12 deficiency is reflected in a huge geographical variation both in requisition of MMA and P-cobalamins and in the vitamin B-12 consumption. On the basis of studies performed so far we conclude that MMA is a reliable method with a good nosographic sensitivity.

Low levels of mannose-binding lectin do not affect occurrence of severe infections or duration of fever in acute myeloid leukaemia during remission induction therapy.

Purpose: To estimate the clinical significance of low serum concentrations of mannose-binding lectin (MBL) in patients with acute myeloid leukaemia (AML) during initial cancer chemotherapy.

Patients And Methods: 80 consecutive, newly diagnosed, and unselected AML patients (age 18-77 yr) undergoing remission induction chemotherapy. The patients were examined for 28 d.

Vitamin B-12 treatment has limited effect on health-related quality of life among individuals with elevated plasma methylmalonic acid: a randomized placebo-controlled study.

Objective: To examine the hypothesis that treatment with vitamin B-12 improves health-related quality of life (HRQOL) in individuals with biochemical signs of vitamin B-12 deficiency.

Design: A randomized placebo-controlled study.

Setting: Municipality of Aarhus, Denmark.