A biomarkers study of human skin fibroblasts exposition to glyphosate-based herbicide using an untargeted and targeted metabolomics approach.

Metabolomics is a valuable tool to assess glyphosate exposure and its potential impact on human health. However, few studies have used metabolomics to evaluate human exposure to glyphosate or glyphosate-based herbicides (GBHs). In this study, an untargeted and targeted metabolomics approach was applied to human skin fibroblasts exposed to the GBH Roundup (GLYP-R).

An exploratory study of volatile and semi-volatile organic compounds in PM atmospheric particles from an outdoor environment in Brazil.

The development of methods for determining volatile and semi-volatile organic compounds in public spaces has become necessary to identify potential health and environmental risks. This study presents a practical methodology for sampling, extracting, detecting, and identifying these compounds in a vehicular traffic region in Belo Horizonte, Brazil. The methodology uses direct-immersion solid phase microextraction (DI-SPME) and static headspace (SHS) to extract SVOCs/VOCs.

Homologous acetylenic acetogenins from Porcelia macrocarpa R.E. (Fries) displayed potent activity against amastigotes from Trypanosoma cruzi.

As part of our continuous study on the Annonaceae species Porcelia macrocarpa, in the present work, eight chemically related 2-alkyl-3-hydroxy-4-methyl-γ-lactones (1-8) were isolated. Their structures were characterised by NMR, MS, and VCD. Their antitrypanosomal activity was evaluated in vitro against intracellular amastigotes with EC values ranged from 13.

Assessing the basis for regulatory crediting of virus LRVs for secondary biological wastewater treatment: A systematic review.

Regulatory frameworks for potable reuse often include stringent log reduction value (LRV) targets to ensure public health protection against exposure to viruses and protozoa. To achieve overall LRV targets and reduce associated capital and operational costs, it is important to maximize LRV credits awarded to each unit process in a potable reuse treatment train. This may include processes that are historically uncredited or undercredited, such as secondary biological wastewater treatment incorporating activated sludge and secondary clarification.

Quantitative Systems Pharmacology-Based Digital Twins Approach Supplements Clinical Trial Data for Enzyme Replacement Therapies in Pompe Disease.

Pompe disease is a rare, progressive neuromuscular disease caused by deficient lysosomal glycogen degradation, and includes both late-onset (LOPD) and severe infantile-onset (IOPD) phenotypes. Due to very small patient numbers in IOPD and the high phenotypic heterogeneity observed in this population, a quantitative systems pharmacology (QSP)-based "digital twin" approach was developed to perform an in silico comparison of the efficacy of avalglucosidase alfa vs. the standard of care, in a virtual population of IOPD patients.