Publications by authors named "J Edson Pontes"
Schizophrenia (SCZ) is a multifactorial mental illness with limited knowledge concerning pathogenesis, contributing to the lack of effective therapies. More recently, the use of a nitric oxide donor named sodium nitroprusside (sNP) was suggested as a potential therapeutic drug for the treatment of SCZ. Despite the mixed results regarding the effectiveness of the sNP in reducing SCZ symptoms, successful trials on sNP in treatment-resistant SCZ were published.
View Article and Find Full Text PDFcan cause invasive pulmonary aspergillosis (IPA). Fungicidal azoles and fungistatic caspofungin (CAS) are the first- and second-line therapies, respectively, used to treat IPA. Treatment of with CAS or micafungin induces the production of the oxylipin 5,8-diHODE by the fungal oxygenase PpoA.
View Article and Find Full Text PDFPurpose: High-risk localized prostate cancer (HRLPC) commonly progresses to metastatic disease after local treatment. Neoadjuvant androgen deprivation therapy (nADT) before radical prostatectomy (RP) has recently been suggested to improve early oncological outcomes in HRLPC. We aimed to perform an exploratory analysis of the pathological outcomes from a prospective trial testing nADT before RP.
View Article and Find Full Text PDFArticle Synopsis
- - The study aimed to explore how transsexual, travesti women, and non-binary or gender-fluid individuals (TGWT+) perceive and experience health services concerning pre-exposure prophylaxis (PrEP) before and during the COVID-19 pandemic.
- - Through 45 semi-structured interviews in São Paulo, researchers found that TGWT+ individuals redefined their struggles and health care practices, highlighting the ongoing challenges posed by both the HIV epidemic and the pandemic.
- - The research suggests that TGWT+ individuals actively engage with health services in meaningful ways, and emphasizes the need for more nuanced studies to enhance prevention and care strategies during health crises.
Magnetic resonance-guided laser interstitial thermal therapy versus open surgical corpus callosotomy for pediatric refractory epilepsy: A systematic review and meta-analysis.
Seizure
November 2024
Purpose: Magnetic resonance-guided laser interstitial thermal therapy (MRgLITT) is a novel, minimally invasive alternative to traditional open surgery corpus callosotomy (CC). We aim to compare both approaches in terms of time of hospitalization and surgical procedure, complications, and efficacy outcomes.
Methods: A systematic search on PubMed, Embase, Web of Science, and Cochrane Library databases was performed for studies directly comparing MRgLITT and open surgery for refractory epilepsy in children.