Publications by authors named "J E de Peyer"

Article Synopsis
  • Recent advancements in aging research and drug discovery connect basic research with clinical applications, aiming to promote healthy longevity in humans.* -
  • The Aging Research and Drug Discovery Meeting in 2023 highlighted key areas such as AI, biomarkers, geroscience, and clinical trials focused on enhancing healthspan.* -
  • The meeting emphasized the importance of combining generative AI with innovative biological technologies to tackle age-related diseases and extend healthy lifespans.*
View Article and Find Full Text PDF

The bone marrow contains peripheral nerves that promote haematopoietic regeneration after irradiation or chemotherapy (myeloablation), but little is known about how this is regulated. Here we found that nerve growth factor (NGF) produced by leptin receptor-expressing (LepR) stromal cells is required to maintain nerve fibres in adult bone marrow. In nerveless bone marrow, steady-state haematopoiesis was normal but haematopoietic and vascular regeneration were impaired after myeloablation.

View Article and Find Full Text PDF

Elevated levels of blood-based proinflammatory cytokines are linked to acute moderate to severe traumatic brain injuries (TBIs), yet less is known in acute mild (m)TBI cohorts. The current study examined whether blood-based cytokines can differentiate patients with mTBI, with and without neuroimaging findings (CT and MRI). Within 24 h of a mTBI, determined by a Glasgow Coma Scale (GCS) between 13 and 15, participants ( = 250) underwent a computed tomography (CT) and magnetic resonance imaging (MRI) scan and provided a blood sample.

View Article and Find Full Text PDF