Publications by authors named "J E Zacher"
Article Synopsis
- Desmin intermediate filaments are important for muscle health, helping with stress management and protection; their breakdown leads to muscle damage and atrophy.
- A study was conducted on 10 healthy individuals who underwent 14 sessions of eccentric accentuated resistance exercise to see how this exercise affects desmin regulation and stability.
- Results showed that resistance exercise alters desmin phosphorylation patterns and reduces its cleavage susceptibility, suggesting that desmin adaptation plays a key role in muscle response to stress and injury over time.
Mid- to long-term cardiac magnetic resonance findings in elite athletes recovered from COVID-19: results from an ongoing observational COVID-19 study at a German Olympic medical centre.
Swiss Med Wkly
December 2023
Introduction: The cardiac magnetic resonance (CMR) data on mid- to long-term myocardial damage due to COVID-19 infections in elite athletes are scarce. Therefore, this study investigated the mid -to long-term consequences of myocardial involvement after a COVID-19 infection in elite athletes.
Materials And Methods: This study included 27 athletes at the German Olympic Centre North Rhine-Westphalia (NRW)/Rhineland with a confirmed previous COVID-19 infection between January 2020 and October 2021.
Lipofuscin (LF) is an intracellular aggregate associated with proteostatic impairments, especially prevalent in nondividing skeletal muscle fibers. Reactive oxygen species (ROS) drive LF-formation. Resistance training (RT) improves muscle performance but also increases ROS production, potentially promoting LF-formation.
View Article and Find Full Text PDFBackground: An infection with SARS-CoV-2 can lead to a variety of symptoms and complications, which can impair athletic activity.
Objective: We aimed to assess the clinical symptom patterns, diagnostic findings, and the extent of impairment in sport practice in a large cohort of athletes infected with SARS-CoV-2, both initially after infection and at follow-up. Additionally, we investigated whether baseline factors that may contribute to reduced exercise tolerance at follow-up can be identified.