Clinical Presentation of Frontal Sinus Squamous Cell Carcinoma in the Dog and Response to Treatment With Radiation Therapy in Eight Dogs.

Primary frontal sinus squamous cell carcinoma (PFSSCC) represents a rare disease in dogs, and there is a general paucity of information in the current veterinary literature regarding its presentation and response to radiation therapy. The objective of this retrospective observational study was to describe a series of dogs diagnosed with PFSSCC and report their response to radiation therapy. Medical records of dogs with a diagnosis of PFSSCC were reviewed.

FDG uptake of pulmonary lesions in synchronous primary lung cancers and lung metastases.

Purpose: In lung cancer patients, the distinction between synchronous primary lung cancer and intrapulmonary metastasis can be challenging. The intensity of FDG uptake in pulmonary lesions has been shown to be potentially useful in classifying synchronous lung cancer. The aim of this retrospective study is to investigate the effectiveness of FDG uptake in differentiating metastases from synchronous primary lesions in the setting of lung cancer.

Disrupted Endoplasmic Reticulum Ca Handling: A Harβinger of β-Cell Failure.

The β-cell workload increases in the setting of insulin resistance and reduced β-cell mass, which occurs in type 2 and type 1 diabetes, respectively. The prolonged elevation of insulin production and secretion during the pathogenesis of diabetes results in β-cell ER stress. The depletion of β-cell Ca during ER stress activates the unfolded protein response, leading to β-cell dysfunction.