Synthesis and evaluation of inhibitors of bacterial drug efflux pumps of the major facilitator superfamily.

Inhibitors of drug efflux pumps have great potential as pharmacological agents that restore the drug susceptibility of multidrug resistant bacterial pathogens. Most attention has been focused on the discovery of small molecules that inhibit the resistance nodulation division (RND) family drug efflux pumps in Gram-negative bacteria. The prototypical inhibitor of RND-family efflux pumps in Gram-negative bacteria is MC-207,110 (Phe-Arg-β-naphthylamide), a C-capped dipeptide.

Trial marriage: Florida's experience in consolidating HIV/AIDS, STD, and TB programs.

After a three-year experiment in consolidating services, the Florida Department of Health has again separated programs for the prevention and control of HIV/AIDS, sexually transmitted diseases (STDs), and tuberculosis. The authors report that while there were some clear advantages to consolidating services, especially programs dealing with HIV and other STDs, the individual programs suffered in some important ways. The authors describe Florida's effort to preserve the positive programmatic and administrative aspects of the consolidated approach and to apply the lessons learned.

Human immunodeficiency virus partner notification. Cost and effectiveness data from an attempted randomized controlled trial.

Objective: Determine the cost and effectiveness of partner notification for human immunodeficiency virus (HIV) infection.

Methods: Persons testing HIV positive in three areas were randomly assigned one of four approaches to partner notification. Analysis plans changed because disease intervention specialists notified many partners from the patient referral group.

Partner notification for syphilis: a randomized, controlled trial of three approaches.

Objective: To determine the cost and effectiveness of three approaches to partner notification for infectious syphilis.

Study Design: People with syphilis were randomly assigned to: (1) notification of partners by patients themselves within 2 days or disease intervention specialists would notify them; (2) immediate notification by intervention specialist; or (3) immediate notification by intervention specialists, who had the option of drawing blood in the field. Costs of intervention specialists' time, travel, and overhead were measured.

Trends in the acquisition of sexually transmitted diseases among HIV-positive patients at STD clinics, Miami 1988-1992.

Background And Objectives: To assess trends in the acquisition of new sexually transmitted diseases (STDs) among patients who test positive for human immunodeficiency virus (HIV) at STD clinics.

Study Design: Cohorts of HIV-positive and HIV-negative persons were compared using computerized records from Miami STD clinics for 1988-1992. Persons were assigned to cohorts according to their first positive or first negative HIV test results.