Publications by authors named "J E Whaley"
Off-Label Bone Morphogenetic Protein 2 Use Results in Successful Posterolateral Lumbar Fusion in a Veteran Population.
J Am Acad Orthop Surg Glob Res Rev
October 2024
Introduction: Patients within the US Veterans Health Administration (VA) system have higher rates of comorbidities and chronic pain, increasing risks of complications/poor outcomes following spine surgery. Although the use of bone morphogenetic protein 2 (BMP-2) is established for anterior lumbar interbody fusion, its indications for off-label use in posterolateral fusion are unclear. The objective of this study was to evaluate safety and utility of BMP-2 in posterolateral fusion through a 15-year experience at the VA.
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- Mastitis impacts the economy and welfare of sheep affected by both clinical and subclinical forms, prompting research on microbial diversity in milk from healthy ewes.
- The study sequenced the V4 region of the 16S rRNA gene from milk collected at various postpartum stages from ewes fed different zinc diets during gestation and lactation.
- Findings revealed diverse microbial communities with notable mastitis-related pathogens present, while the effects of breed, dietary zinc, and somatic cell counts on milk microbiome diversity varied, particularly during early lactation.
Animal drug shortages limit veterinary therapeutic options and introduce artifacts in antimicrobial sales reporting.
J Am Vet Med Assoc
April 2024
Supply chain issues disrupt veterinary care and cause downstream consequences that alter the practice of veterinary medicine. Antimicrobials are just 1 class of pharmaceuticals that have been impacted by supply chain issues over the last couple of years. Since February 2021, 2 sponsors/manufacturers of penicillin products have reported shortages in the active pharmaceutical ingredient.
View Article and Find Full Text PDFCurrently, immunotherapy based on PD-1/PD-L1 pathway blockade has improved survival of non-small cell lung cancer (NSCLC) patients. However, differential responses have been observed by sex, where men appear to respond better than women. Additionally, adverse effects of immunotherapy are mainly observed in women.
View Article and Find Full Text PDFA series of dihydropyridinone (DHP) compounds was prepared and evaluated for MGAT2 activity. The efforts led to the identification of novel tetrazolones with potent MGAT2 inhibitory activity and favorable profiles. Further tests of select analogues in mouse models revealed significant reduction in food intake and body weight.
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