Emerin Dysregulation Drives the Very-Small-Nuclear Phenotype and Lineage Plasticity that Associates with a Clinically Aggressive Subtype of Prostate Cancer.

Background: Circulating tumor cells (CTCs) with a very-small-nuclear phenotype (vsnCTCs) in prostate cancer (PCa) are characterized by nuclei smaller than 8.5 μm. Our previous studies established an association between vsnCTCs and visceral metastasis.

Dynamic and context-dependent keystone species effects in kelp forests.

Sea otters are an iconic keystone predator that can maintain kelp forests by preying on grazing invertebrates such as sea urchins. However, the effects of sea otters on kelp forests vary over their geographic range. Here, we analyze two 30-y datasets on kelp forest communities during the reintroduction of sea otters along the west coast of Vancouver Island, BC, Canada, and around San Nicolas Island, CA.

Regulation of lipid dysmetabolism and neuroinflammation linked with Alzheimer's disease through modulation of Dgat2.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-β (Aβ) plaque accumulation, cognitive decline, lipid dysregulation, and neuroinflammation. Mutations in the Amyloid Precursor Protein (APP), and accumulation of A contribute to AD, however, underlying mechanisms linking beta amyloid to lipid metabolism and neuroinflammation remain unclear. Using models, we demonstrate that and lead to progressive locomotor impairments, disrupted sleep activity, memory deficits, lipid dysregulation, loss of synaptic integrity, and neuroinflammation.

The mutation in mapped as a novel allele of ​​ .

In genetic screens are often used to identify genes associated with different biological processes. Here, we have utilized the Flp/FRT system to generate mitotic clones within the developing eye. These clones were screened for mutations that disrupt cell division, organ patterning, and cell growth.

Diagnostic Accuracy of a Nasal Rapid Staphylococcus aureus PCR Test in Intubated Children With Severe Community-Acquired Pneumonia.

Observational studies demonstrate that nasal methicillin-resistant Staphylococcus aureus (MRSA) surveillance swabs have a high negative predictive value for MRSA infections. This prospective study of 94 children intubated for severe pneumonia showed a negative predictive value of >99% for rapid MRSA nasal polymerase chain reaction swabs performed at diagnosis, suggesting they could aid initial antibiotic prescription in critically ill children with pneumonia.