Aging Favors Calcium Activation of Ryanodine Receptor Channels from Brain Cortices and Hippocampi and Hinders Learning and Memory in Male Rats.

The response of ryanodine receptor (RyR) channels to increases in free cytoplasmic calcium concentration ([Ca]) is tuned by several mechanisms, including redox signaling. Three different responses to [Ca] have been described in RyR channels, low, moderate and high activity responses, which depend on the RyR channel protein oxidation state. Thus, reduced RyR channels display the low activity response, whereas partially oxidized channels display the moderate response and more oxidized channels, the high activity response.

Understanding Mantle Edge Pigmentation Through Comprehensive Transcriptomic Profiling of the Chilean Oyster ().

The Chilean oyster () is a flat oyster native to Chile and New Zealand. Over-exploitation has led to local extinctions in some areas. Two phenotypes, distinguished by dark or white mantle edge pigmentation, have been identified, with the dark-edged mantle oysters being more commercially valuable due to perceived quality.

Upwelling effects across different levels of biological organization: Integrating biochemical constituents, physiological performance and muscle transcriptomic response in the intertidal FISH Girella laevifrons (kyphosidae).

The physical-chemical variability of coastal upwelling creates a mosaic of environmental conditions that affect different levels of biological organization. Understanding the mechanisms that organisms use to cope with this variability is critical for addressing the challenges that climate change imposes on coastal ecosystems. This study integrates information on transcriptomic traits, metabolic performance, and the quantity of organic biomolecules in the intertidal fish Girella laevifrons from four locations with varying upwelling intensities.

Modelling protein-protein interactions for the design of vaccine chimeric antigens with protective epitopes.

Ticks and tick-borne diseases are a growing burden worldwide and vaccines are effective control interventions. Vaccine formulations with tick antigens such as BM86/BM95 (BM) and Subolesin (SUB) have shown reduction in tick fitness and infestation in immunized hosts. However, antigen combination is a challenging approach to improve vaccine efficacy (E) against multiple tick species.

High temperature induces oxidative damage, immune modulation, and atrophy in the gills and skeletal muscle of the teleost fish black cusk-eel (Genypterus maculatus).

The high temperature associated with heat waves is a relevant abiotic factor that could impact the biology of teleost fish. The innate immune response, muscular growth, and oxidative stress status are relevant functions in fish tissues that could be affected by increased temperature. In this study, black cusk-eel (Genypterus maculatus) juveniles were subjected to increased temperature, to experimentally replicate heat waves registered from the South Pacific Ocean for five days.