Publications by authors named "J E V Guzman"

Quantifying competition load with kinematic variables from inertial devices provides critical insights into player performance, a practice well adopted especially in team sports. This study aimed to analyse load variables in elite padel players, distinguishing between match winners and losers. Data were collected from 83 players across 23 professional circuit matches.

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  • Biological aging involves a gradual loss of homeostasis in molecular and cellular functions, particularly in the brain, which contains diverse cell types that differ in their aging resilience.
  • This study offers an extensive single-cell RNA sequencing dataset of approximately 1.2 million transcriptomes from brain cells in young and aged mice, identifying 847 cell clusters and 14 age-biased clusters predominantly involving glial types.
  • Key findings reveal specific gene expression changes with aging, including decreased neuronal function genes and increased immune-related genes, particularly in cells around the third ventricle of the hypothalamus, suggesting its critical role in the aging process of the mouse brain.
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The Nipah virus (NiV), a highly pathogenic zoonotic virus of the family, poses significant threats with its alarming mortality rates and pandemic potential. Despite historical cases, effective therapeutics remain elusive, prompting urgent exploration of potential antivirals. In this study, a structure-based virtual screening approach was employed to evaluate 690 metabolites sourced from ten medicinal plants () for their antiviral activity against Nipah virus proteins.

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The lack of a classical adaptive immunity renders the development of disease control and prevention measures in shrimp challenging. In this study, the concept of trained immunity was exploited in the development of a feed supplement. Penaeus vannamei shrimp was fed with feed supplemented with freeze-dried whole culture of Lactiplantibacillus plantarum (FD-LAB) for 15 days.

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  • * The study characterized over 5700 proteins in coho salmon ovaries, revealing significant changes during the transition from primary to secondary ovarian follicle development, which is vital for egg quality and embryonic development.
  • * Key findings indicate that metabolic processes and protein functions involved in follicle growth and cell signaling change dramatically during this transition, laying groundwork for identifying biomarkers for salmon egg quality.
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