Publications by authors named "J E Tilton"
The HIV-1 protease is a critical enzyme for viral replication. Because protease activity is necessary to generate mature infectious virions, it is a primary target of antiretroviral treatment. Here, we provide an overview of the mechanisms regulating protease activation and the methods available to assess protease activity.
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- This study evaluated the cost-effectiveness of a pharmacist-led medication therapy management clinic (MTMC) for type 2 diabetes compared to usual care, using a simulation model that incorporated diabetes effects and complications.
- Results showed that MTMC had a total cost of $160,145 and 6.73 quality-adjusted life-years (QALYs), while usual care had costs of $152,806 and 6.65 QALYs, yielding an incremental cost-effectiveness ratio (ICER) of $93,375 per QALY gained, which is deemed cost-effective.
- The findings suggest that including clinical pharmacy services may enhance healthcare strategies and support broader reimbursement for such services to improve
HIV-1 protease inhibitors are an essential component of antiretroviral therapy. However, drug resistance is a pervasive issue motivating a persistent search for novel therapies. Recent reports found that when protease activates within the host cell's cytosol, it facilitates the pyroptotic killing of infected cells.
View Article and Find Full Text PDFThis review focuses on the emerging field of flow virometry, the study and characterization of individual viral particles using flow cytometry instruments and protocols optimized for the detection of nanoscale events. Flow virometry faces considerable technical challenges including minimal light scattering by small viruses that complicates detection, coincidental detection of multiple small particles due to their high concentrations, and challenges with sample preparation including the inability to easily "wash" samples to remove unbound fluorescent antibodies. We will discuss how the field has overcome these challenges to reveal novel insights into viral biology.
View Article and Find Full Text PDFImportance: Clinical pharmacists and health coaches using mobile health (mHealth) tools, such as telehealth and text messaging, may improve blood glucose levels in African American and Latinx populations with type 2 diabetes.
Objective: To determine whether clinical pharmacists and health coaches using mHealth tools can improve hemoglobin A1c (HbA1c) levels.
Design, Setting, And Participants: This randomized clinical trial included 221 African American or Latinx patients with type 2 diabetes and elevated HbA1c (≥8%) from an academic medical center in Chicago.