Publications by authors named "J E Shirley"

Article Synopsis
  • - Penicillin-binding proteins (PBPs) are crucial bacterial enzymes that can be inhibited by β-lactam antibiotics, disrupting their ability to grow and divide, ultimately leading to cell lysis.
  • - Traditional metrics like IC values for measuring enzyme inhibition can be misleading, especially for covalent inhibitors, making the second-order rate constant (k) a better measure of potency.
  • - The researchers created a whole-cell k assay using a fluorescent probe to assess β-lactam potency across multiple PBPs, confirming its effectiveness in relation to existing IC values and supporting further structure-activity relationship studies.
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is a rapidly growing nontuberculous mycobacterium that is rarely isolated from clinical specimens and is frequently considered to be a contaminant. We conducted a retrospective review of mycobacterial cultures positive for from 1998 to 2023 at our institution to evaluate the clinical significance of recovering this mycobacterium. Antimicrobial susceptibility patterns were also determined.

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In April 2023, a distinguished panel of scientists, advocates, and child health policy experts convened by the American Enterprise Institute (AEI) issued a report entitled, "Why Foster Children Are Sleeping in Offices and What We Can Do About It." It concluded that the 2018 Family First Prevention Services Act (FFPSA), which was intended to protect children and adolescents from hazards of institutional care, precipitated a cascade of unintended consequences resulting in large numbers of foster children and adolescents with higher levels of need living in a range of inappropriate settings, including child welfare offices, emergency rooms, hotels, and homeless shelters. Across the United States, FFPSA resulted in severe shortages of placement options for undomiciled foster youth, which were precipitated by constraints in the following: (1) resources, (2) qualifications for reimbursement eligibility, and (3) numbers of beds (by broad extension of the institutions for mental disease [IMD] exclusion in Medicaid restricting bed capacity to 16) for congregate care settings that could otherwise be providing compassionate, qualified, appropriate care to this vulnerable population.

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Background: Physical inactivity is recognized as a global health challenge. Attachment theory may provide insight into individual physical activity (PA) patterns, informing the development of PA interventions to promote the maintenance of behavior change. This study investigated the associations between attachment orientation and why and how individuals engage in PA.

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The heterogeneity of autism spectrum disorder (ASD) clinically and aetiologically hinders intervention matching and prediction of outcomes. This study investigated if the behavioural, sensory, and perinatal factor profiles of autistic children could be used to identify distinct subgroups. Participants on the autism spectrum aged 2 to 17 years and their families were sourced via the Australian Autism Biobank (AAB).

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