Publications by authors named "J E Sevransky"
Progress in the management of critical care syndromes such as sepsis, Acute Respiratory Distress Syndrome (ARDS), and trauma has slowed over the last two decades, limited by the inherent heterogeneity within syndromic illnesses. Numerous immune endotypes have been proposed in sepsis and critical care, however the overlap of the endotypes is unclear, limiting clinical translation. The SUBSPACE consortium is an international consortium that aims to advance precision medicine through the sharing of transcriptomic data.
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- * This study highlights that serum Angiotensinogen levels are better indicators of 30-day mortality in sepsis patients than lactate or renin levels, suggesting a dysfunctional renin-angiotensin system in these cases.
- * Evaluating Angiotensinogen could improve treatment strategies for sepsis, potentially leading to better patient outcomes, but further studies are needed to validate its effectiveness as a biomarker.
Article Synopsis
- The study tracks changes in patient characteristics and medical care for those hospitalized with severe acute respiratory infections during different COVID-19 pandemic phases in the U.S.
- It involves a longitudinal cohort study of 874 patients across multiple hospitals, focusing on demographics, health conditions, and treatment outcomes corresponding to different SARS-CoV-2 variants.
- The findings highlight the evolution of patient outcomes and emphasize the need for a continuous clinical network to better understand both known and new respiratory viral diseases.
Objective: Sepsis is a leading cause of mortality. Predicting outcomes is challenging and few biomarkers perform well. Defects in the renin-angiotensin system (RAS) can predict clinical outcomes in sepsis and may outperform traditional biomarkers.
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