Publications by authors named "J E Seegmiller"
Introduction: Serum cystatin C (CysC) is used to estimate glomerular filtration rate (eGFR), including in the Chronic Kidney Disease in Children (CKiD) Under 25 years (U25eGFR) equations. Several CysC measurement procedures available from diagnostic vendors include reference material for calibration, but the extent of heterogeneity across manufacturers is unclear. Since heterogeneity may have clinical and research implications for eGFR, we evaluated three CysC procedures in samples from the CKiD study representing a wide spectrum of kidney function.
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- Assessing glomerular filtration rate (GFR) is essential for kidney disease management, but current methods, particularly estimated GFR (eGFR), can have significant errors affecting patient care.
- Researchers propose using a panel of multiple filtration markers, alongside non-GFR determinants, to enhance the accuracy of these estimates, building on previous findings that cystatin C improves eGFR precision.
- Initial evaluations indicate that applying techniques like outlier identification and transfer learning can significantly improve eGFR accuracy, even in populations where traditional methods struggle.
Rationale & Objective: The prevalence of chronic kidney disease (CKD) is known to increase with age; however, creatinine may be a less reliable filtration marker in older adults. Few studies have investigated the prevalence and progression of CKD using different filtration markers for estimating glomerular filtration rate (GFR).
Study Design: A prospective observational cohort study.