Publications by authors named "J E Schupp"
Article Synopsis
- - The proteasome is essential for maintaining cellular balance by breaking down damaged or unnecessary proteins, and its regulation—especially through proteins with the HbYX motif—is crucial for understanding its function.
- - ProEnd is a new database created to identify and catalog proteins containing the HbYX motif from a vast analysis of around 73 million proteins across 22,000 reference proteomes, revealing the motif's importance and evolutionary conservation in many organisms, particularly in viruses.
- - The database also validated two newly discovered HbYX proteins that interact with the proteasome, with one of them shown to activate it, paving the way for new research and potential therapies for diseases like neurodegenerative disorders and cancer.
Article Synopsis
- Developmental transcription factors, like PBX1, function in complex networks whose specificity in cells and tissues remains unclear.
- Through various genomic techniques, the study revealed that PBX1 interacts with multiple partners, including TCF3 and TCF4, which play important roles in adult neurogenesis.
- The research highlights a potential cooperation between PBX1 and TCF3 in cell proliferation, suggesting their interaction may also be relevant in leukemia, particularly due to the presence of a TCF3::PBX1 fusion in a subtype of acute lymphoblastic leukemia.
Neurodegenerative diseases are characterized by the presence of misfolded and aggregated proteins which are thought to contribute to the development of the disease. In one form of inherited blinding disease, retinitis pigmentosa, a P23H mutation in the light-sensing receptor, rhodopsin causes rhodopsin misfolding resulting in complete vision loss. We investigated whether a xenogeneic protein-unfolding ATPase (unfoldase) from thermophilic Archaea, termed PANet, could counteract the proteotoxicity of P23H rhodopsin.
View Article and Find Full Text PDFIn liposomal drug delivery development, the delicate balance of membrane stability is a major challenge to prevent leakage (during shelf-life and blood circulation), and to ensure efficient payload release at the therapeutic destination. Our composite screening approach uses the processing by dual centrifugation technique to speed up the identification of de novo formulations of intermediate membrane stability. By screening binary lipid combinations at systemically varied ratios we highlight liposomal formulations of intermediate stability, what we termed "the edge of stability", requiring moderate stimuli for destabilization.
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