Publications by authors named "J E Sarnat"
Article Synopsis
- The study assessed the impact of various air pollutants on metabolic changes in a large group of 1,096 women over the age of 65, utilizing blood samples collected between 1998 and 2001.
- Significant associations were found between air pollutants such as particulate matter and nitrogen dioxide and 95 metabolites involved in processes like oxidative stress and inflammation, with 60 metabolites showing strong evidence linking them to air pollution.
- This research confirms and expands upon previous studies by highlighting biological responses to long-term exposure to air pollution, utilizing a sophisticated analysis of pollutant mixtures.
Prenatal and early life air pollution exposure has been linked with several adverse health outcomes. However, the mechanisms underlying these relationships are not yet fully understood. Therefore, this study utilizes fecal metabolomics to determine if pre- and postnatal exposure to ambient air pollutants (i.
View Article and Find Full Text PDFBackground: A better understanding of lung cancer etiology and the development of screening biomarkers have important implications for lung cancer prevention.
Methods: We included 623 matched case-control pairs from the Cancer Prevention Study (CPS) cohorts. Pre-diagnosis blood samples were collected between 1998 and 2001 in the CPS-II Nutrition cohort and 2006 and 2013 in the CPS-3 cohort and were sent for metabolomics profiling simultaneously.
Article Synopsis
- Residential biomass burning significantly contributes to black carbon (BC) exposure in rural communities, especially among pregnant women in low- and middle-income countries.
- In a study involving 3103 pregnant women, those who received liquefied petroleum gas stoves showed much lower BC exposure (2.8 μg/m) compared to those using traditional biomass stoves (9.6 μg/m).
- The study identified primary stove type as the strongest predictor of BC exposure, and highlights the need to consider various factors, such as kitchen location and adherence to stove use, to improve the efficacy of cookstove intervention trials.
A potentially important approach for reducing exposure to traffic-related air pollution (TRAP) is the use of roadside barriers to reduce dispersion from highway sources to adjacent populated areas. The Trees Reducing Environmental Exposures (TREE) study investigated the effect of vegetative and solid barriers along major controlled-access highways in Atlanta, Georgia, USA by simultaneously sampling TRAP concentration at roadside locations in front of barriers and at comparison locations down-range. We measured black carbon (BC) mass concentration, particle number concentration (PNC), and the size distribution of ultrafine aerosols.
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