Cod Liver Oil, but Not Retinoic Acid, Treatment Restores Bone Thickness in a Vitamin A-Deficient Rat.

Vitamin A plays a prominent role for maintaining optimal bone status, but its impact upon the bone in response to vitamin A deficiency is not well defined. The purpose of this study was to evaluate how replenishing vitamin A by either whole food cod liver oil (COD) or the active metabolite of vitamin A, retinoic acid (RA), altered bone thickness of vitamin A-deficient (VAD) rats. Weanling rats were administered a control diet (CTRL) or VAD diet for 9 weeks.

The reaction of O(P) with alkynes: a dynamic and computational study focusing on formyl radical production.

Production of formyl radical, HCO, from reactions of O(P) with alkynes (acetylene, propyne, 1-butyne, and 1-pentyne) has been investigated using cavity ringdown laser absorption spectroscopy (CRDLAS) and computational methods. No HCO was detected from reaction with acetylene, while the amount of HCO increased for propyne and 1-butyne, dropping off somewhat for 1-pentyne. These results differ from trends previously observed for reactions of O(P) with alkenes, which exhibit the largest HCO production for the smallest alkene and drop off as the alkene size increases.

Integrating SERS and PSI-MS with Dual Purpose Plasmonic Paper Substrates for On-Site Illicit Drug Confirmation.

Forensic laboratory backlogs are replete with suspected drug samples. Shifting analysis toward the point of seizure would save significant time and public funds. Moreover, a two-tiered identification strategy for controlled substance testing that relies on two independent, discerning methods could entirely circumvent the need for forensic laboratory testing.

Effects of Solvation and Hydrogen Bond Formation on Singlet and Triplet Alkyl or Aryl Carbenes.

Formation of hydrogen-bonded complexes involving singlet and triplet alkyl or aryl carbenes and the impacts of solvation and hydrogen bonding upon the carbene singlet-triplet gaps have been investigated using computational methods. Single-point CCSD(T)-F12 and MRCI+Q methodologies have been employed with aug-cc-pVDZ and aug-cc-pVTZ basis sets to determine accurate singlet-triplet gaps of carbenes and hydrogen-bonded complexes involving carbenes, with geometries and vibrational frequencies obtained at the B3LYP-D3/aug-cc-pVTZ level. Using the PCM continuum solvent method and density functional theory (B3LYP/aug-cc-pVTZ), the singlet-triplet gaps of the carbenes are found to exhibit significant solvent effects; due its higher polarity, the singlet carbene is stabilized to a greater degree than the corresponding triplet carbene, impacting the singlet-triplet gap by as much as 4.