Publications by authors named "J E Ruffin"
Purpose: Gap-balanced total knee arthroplasty (TKA) technique relies on initial ligament evaluation, particularly in patient-specific implantation using computer-assisted technologies. This cadaveric study aimed to compare the reproducibility and reliability of medial and lateral gap measurements between manual stress testing and dynamic ligament balancer.
Methods: Initial gap acquisitions were assessed from eight cadaveric knees (four specimens) during the same navigated TKA procedure by five differently skilled surgeons (three seniors and two juniors).
Background: Understanding protection against SARS-CoV-2 infection by vaccine and hybrid immunity is important for informing public health strategies as new variants emerge.
Methods: We analyzed data from three cohort studies spanning September 1, 2022-July 31, 2023, to estimate COVID-19 vaccine effectiveness (VE) against SARS-CoV-2 infection and symptomatic COVID-19 among adults with and without prior infection in the United States. Participants collected weekly nasal swabs, irrespective of symptoms, annual blood draws, and completed periodic surveys, which included vaccination status and prior infection history.
Article Synopsis
- A study was conducted from September 2022 to April 2023 to evaluate how COVID-19 vaccines affect the risk of infection in children under 5 years old.
- The results showed no significant difference in infection risk between vaccinated and unvaccinated children.
- Although the vaccines are effective in preventing severe illness, they may not prevent the actual infection of the virus in young kids.
Eukaryotic gene expression is regulated at the transcriptional and post-transcriptional levels, with disruption of regulation contributing significantly to human diseases. The 5' m7G mRNA cap is a central node in post-transcriptional regulation, participating in both mRNA stabilization and translation efficiency. In mammals, DCP1a and DCP1b are paralogous cofactor proteins of the mRNA cap hydrolase DCP2.
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- Health equity science focuses on understanding the social determinants of health inequities, with tools like the Social Vulnerability Index (SVI) used during the COVID-19 response to identify vulnerable communities for vaccination efforts.
- The study analyzed COVID-19 vaccination data across US counties from December 2020 to December 2022, categorizing counties by levels of vulnerability and urban vs. rural status to assess vaccination coverage among different age groups.
- Results showed that while older adults had higher vaccination rates, younger populations, especially in rural areas, faced significant gaps in coverage, highlighting the need for more comprehensive health equity analyses beyond just demographics like race and ethnicity.