Publications by authors named "J E Rame"
Macitentan is a dual endothelin receptor antagonist (ERA) approved for treating pulmonary arterial hypertension (PAH). SOPRANO evaluated the efficacy and safety of macitentan versus placebo in pulmonary hypertension (PH) patients after left ventricular assist device (LVAD) implantation. SOPRANO was a phase 2, multicenter, double-blind, randomized, placebo-controlled, parallel-group study.
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- Pre-transplant weight change significantly influences post-heart transplant (HTx) survival, with limited previous research on this topic.
- An analysis of over 9,600 patients revealed that weight loss (over 10 kg or 3 BMI points) increases the risk of death after the transplant, while some weight gain in non-obese patients can improve survival rates.
- The study highlights that the effects of weight change before HTx depend on a patient's initial body mass index (BMI), emphasizing the need for personalized weight management strategies.
Purpose: We sought to investigate the clinical results of preemptive temporary right ventricular assist device (RVAD) placement with left ventricular assist device (LVAD) implantation for anticipated right ventricular failure.
Methods: Patients at risk for right ventricular failure were identified by the heart team. After median sternotomy, Protekduo (LivaNova, London, UK) dual-stage cannula was inserted from the right internal jugular vein under fluoroscopy guidance, and advanced into the pulmonary artery to the bifurcation of the main pulmonary artery.
Article Synopsis
- * Recent findings indicate that the heart increasingly relies on ketone bodies for energy, and higher blood levels of these compounds are linked to the severity of heart dysfunction, suggesting their value in prognosis.
- * There is potential for therapeutic interventions aimed at metabolic pathways to improve heart failure outcomes; however, research must resolve the balance between supporting metabolism and preventing worsening of heart conditions.