Publications by authors named "J E Rainger"
Background: Post-traumatic distal limb wounds cause discomfort and heal gradually by second intention. The topical application of Tri-Solfen (lidocaine hydrochloride, bupivacaine hydrochloride, adrenaline acid tartrate and cetrimide [LBAC]) produces effective postsurgical cutaneous analgesia in lambs, calves and piglets; however, its effect on wounds in horses is unknown.
Methods: The antinociceptive effect, measured by mechanical threshold (MT), and the wound healing impacts of LBAC compared with saline were investigated on surgically created 20 × 20 mm distal limb wounds in 10 horses.
Cell adhesion marker expression dynamics during fusion of the optic fissure.
Gene Expr Patterns
December 2023
Tissue fusion is a critical process that is repeated in multiple contexts during embryonic development and shares common attributes to processes such as wound healing and metastasis. Ocular coloboma is a developmental eye disorder that presents as a physical gap in the ventral eye, and is a major cause of childhood blindness. Coloboma results from fusion failure between opposing ventral retinal epithelia, but there are major knowledge gaps in our understanding of this process at the molecular and cell behavioural levels.
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- The eye field (EF) in the neural plate is the first identifiable stage of eye development, dependent on specific transcription factors.
- Research using optic vesicle organoids provides insights into gene expression changes that occur during the transition of cells to the EF state.
- By examining chromatin accessibility and testing potential enhancer elements in these organoids, the study seeks to understand how transcription factors regulate these developmental processes.
Ocular coloboma (OC) is a failure of complete optic fissure closure during embryonic development and presents as a tissue defect along the proximal-distal axis of the ventral eye. It is classed as part of the clinical spectrum of structural eye malformations with microphthalmia and anophthalmia, collectively abbreviated to MAC. Despite deliberate attempts to identify causative variants in MAC, many patients remain without a genetic diagnosis.
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- The study investigates a form of aniridia and microphthalmia linked to mutations in the MAB21L1 gene, particularly alterations at the Arg51 codon, in patients who do not have typical PAX6 mutations.
- Researchers identified that these mutations appeared de novo in some families and suggested a possible autosomal dominant inheritance pattern.
- Experimental results show that these mutations impact eye development by affecting the function and association of MAB21L1 with various proteins, indicating a potential gain-of-function mechanism rather than a loss-of-function, which is different from typical MAB21L1 mutations leading to milder eye issues.