An integrative proteotranscriptomics approach reveals new ADAM9 substrates and downstream pathways.

Membrane protein shedding is a key regulatory mechanism for cell signaling and adhesion, and dysregulated shedding is associated with diseases. Many membrane proteases can catalyze shedding, but the substrate spectra and downstream targets of these "sheddases" remain largely elusive. While secretomics-based methods have been applied to the systematic identification of sheddase substrates, these methods are not always effective and do not provide much information on downstream targets.

Conversational Engagement Using a Short Message Service Chatbot After Total Joint Arthroplasty.

Background: Utilizing conversational analytics in orthopaedic surgery may provide insights into patients' experiences and outcomes. This study retrospectively assessed how patients interacted with a perioperative chatbot and whether the topic of patients' queries could offer insight on their outcomes after total knee or hip arthroplasty.

Methods: We identified 1338 patients (746 knees and 592 hips) who enrolled in a short message service chatbot from 2020-2022 with greater than 3 months of follow-up.

Use of computed tomography for shoulder arthroplasty: A systematic review.

Introduction: The prevalence of total shoulder arthroplasties is on the rise annually. Improvements in implant quality, construct stability, and surgical techniques have notably enhanced post-operative results, prompting an expansion of indications for shoulder arthroplasty. Despite its high success rate, opportunities for enhancement remain, especially in preoperative planning and intraoperative execution.

Patient Engagement Platforms: How Technology Is Impacting Perioperative Communication and Engagement in Total Hip and Knee Arthroplasty.

Orthopedic clinics are becoming strained with clinical volume outpacing resources and personnel. Patient engagement platforms can help bridge the communication and engagement gaps between patients and their healthcare teams as total hip and knee arthroplasty transitions to the outpatient setting. These platforms provide a digital infrastructure that allows patients to participate in their healthcare journey while alleviating the burdens on clinic staff.

The Growing Role of Artificial Intelligence and Technology in Hip and Knee Arthroplasty.

Artificial intelligence and technology have continued to evolve over recent decades, and their utility in hip and knee arthroplasty is growing with interest and enthusiasm. A multitude of technologies are available to assist surgeons in the intraoperative execution of hip and knee arthroplasty, ranging from robotics and augmented reality to artificial intelligence-powered fluoroscopy. The purpose of this review is to provide a framework for arthroplasty surgeons to understand the concept of artificial intelligence and the advancements in technologies that impact the perioperative care of patients undergoing hip and knee arthroplasty.