Publications by authors named "J E Purcell"
Supergenes in organismal and social development of insects: ideas and opportunities.
Curr Opin Insect Sci
December 2024
Article Synopsis
- Supergenes are linked mutations in the genome that influence complex traits, playing a significant role in the diversity of physical characteristics in insects.
- Research aims to identify common features and evolution patterns of supergenes across different systems.
- Understanding how new supergene variants emerge and affect population dynamics will enhance knowledge of factors like recombination rates that guide evolution in sexually reproducing species.
Article Synopsis
- * Researchers used functional MRI to analyze brain responses in 301 participants while measuring their past discrimination experiences from ages 11 to 19 and current psychological symptoms like depression and anxiety.
- * Findings indicate that brain activity in specific areas (like the prefrontal cortex and hippocampus) related to stress response was influenced by the amount and pattern of discrimination experienced, suggesting that such exposure can alter emotional regulation and increase vulnerability to mental health issues.
Article Synopsis
- Acthar Gel is used to treat various inflammatory disorders and is usually administered with a syringe, but the SelfJect™ prefilled injector aims to make this process easier for subcutaneous delivery.
- The review focused on factors like skin depth and needle gauge to assess SelfJect's suitability for children, noting that infants may be at risk of inadvertent intramuscular injections, but these pose no additional risk due to the drug's effectiveness in either method.
- While SelfJect is generally safe for children and adolescents under supervision, it is recommended that an adult administer the device to ensure proper use and avoid potential adverse effects at the injection site.
Poly (ADP-ribose) glycohydrolase (PARG) inhibitors are currently under clinical development for the treatment of DNA repair-deficient cancers; however, their precise mechanism of action is still unclear. Here, we report that PARG inhibition leads to excessive PARylated poly (ADP-ribose) polymerase 1 (PARP1) reducing the ability of PARP1 to properly localize to sites of DNA damage. Strikingly, the mis-localized PARP1 accumulates as aggregates throughout the nucleus.
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