Publications by authors named "J E Pickett"
Atherosclerosis is a chronic inflammatory vascular disorder driven by factors such as endothelial dysfunction, hypertension, hyperlipidemia, and arterial calcification, and is considered a leading global cause of death. Existing atherosclerosis models have limitations due to the absence of an appropriate hemodynamic microenvironment and interspecies differences . Here, we develop a simple but robust microfluidic intimal-lumen model of early atherosclerosis using interconnected dual channels for studying monocyte transmigration and foam cell formation at an arterial shear rate.
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- Respiratory syncytial virus (RSV) commonly causes respiratory illnesses, especially severe in adults over 60 or those with chronic conditions; a study examined the cost-effectiveness of the RSVPreF3 vaccine for this age group in the US.* -
- A multi-cohort Markov model compared outcomes of not vaccinating versus a one-time vaccination, estimating that vaccinating approximately 52.7 million older adults would save nearly 244,424 quality-adjusted life years (QALYs) at a societal cost of about $4.5 billion over five years.* -
- The analysis indicated that the adjuvanted RSVPreF3 vaccine is cost-effective, with an incremental cost-effectiveness ratio (
Background: Pseudomyxoma peritonei (PMP) is a clinical syndrome characterised by intraperitoneal accumulation of mucus due to mucinous neoplasia. It is a rare condition affecting 1-2 per million individuals per year. The majority of PMP arises from a ruptured mucinous appendiceal tumour, with infrequent occurrences from other primary gastrointestinal tumours and mucinous ovarian tumours.
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- The use of whole blood for medical emergencies before patients reach the hospital is on the rise.
- Existing methods for delivering blood, like intraosseous and peripheral venous catheters, can slow down the flow of these critical fluids during resuscitation.
- Central venous catheters offer a more effective option in prehospital settings, allowing for faster and larger volumes of blood infusion that can save lives.
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- Premature infants face potential long-term challenges like lower effortful control, which can negatively impact academic achievement, peer relationships, and overall wellness throughout their lives.
- The study investigates the interactions between genetics, early birth, and complications at birth to understand their effects on the development of effortful control from 12 months to 10 years using data from a twin cohort in Arizona.
- Results indicated that effortful control, particularly attentional focus, is strongly influenced by genetics rather than gestational age or early complications, highlighting the different origins of each subdomain of effortful control.