First-Time Father's Risk Factors of Paternal Perinatal Psychological Distress: A Scoping Review.

Fathers can experience psychological distress during the paternal perinatal period. The effects of paternal perinatal psychological distress (PPPD) are multileveled. Little research is available about PPPD in first-time fathers.

Spatial 3D genome organization reveals intratumor heterogeneity in primary glioblastoma samples.

Glioblastoma (GBM) is the most prevalent malignant brain tumor with poor prognosis. Although chromatin intratumoral heterogeneity is a characteristic feature of GBM, most current studies are conducted at a single tumor site. To investigate the GBM-specific 3D genome organization and its heterogeneity, we conducted Hi-C experiments in 21 GBM samples from nine patients, along with three normal brain samples.

Correcting Lab Misinterpretations of Variants of Unknown Significance: A Case Study of EMILIN1 Variants in an Autosomal Recessive Disorder.

A nine-month-old male was referred with short stature, tortuosity in multiple arteries, pulmonary stenosis, and multiple fractures. Trio exome sequencing (ES) revealed a c.275_277delinsTT, p.

Accurate volume image reconstruction for digital breast tomosynthesis with directional-gradient and pixel sparsity regularization.

Purpose: We aim to develop accurate volumetric quantitative imaging of iodinated contrast agent (ICA) in contrast-enhanced digital breast tomosynthesis (DBT).

Approach: The two main components of the approach are the use of a dual-energy DBT (DE-DBT) scan and the development of an optimization-based algorithm that can yield accurate images with isotropic resolution. The image reconstruction algorithm exploits sparsity in the subject's directional derivative magnitudes, and it also performs direct sparsity regularization to help confine the reconstruction to the true support of the subject.

Longitudinal profiling of IDH-mutant astrocytomas reveals acquired RAS-MAPK pathway mutations associated with inferior survival.

Background: Isocitrate dehydrogenase (IDH)-mutant astrocytomas represent the most frequent primary intraparenchymal brain tumor in young adults, which typically arise as low-grade neoplasms that often progress and transform to higher grade despite current therapeutic approaches. However, the genetic alterations underlying high-grade transformation and disease progression of IDH-mutant astrocytomas remain inadequately defined.

Methods: Genomic profiling was performed on 205 IDH-mutant astrocytomas from 172 patients from both initial treatment-naive and recurrent post-treatment tumor specimens.