Machine learning to predict dementia for American Indian and Alaska native peoples: a retrospective cohort study.

Background: Dementia is an increasing concern among American Indian and Alaska Native (AI/AN) communities, yet machine learning models utilizing electronic health record (EHR) data have not been developed or validated for this population. This study aimed to develop a two-year dementia risk prediction model for AI/AN individuals actively using Indian Health Service (IHS) and Tribal health services.

Methods: Seven years of data were obtained from the IHS National Data Warehouse and related EHR databases and divided into a five-year baseline period (FY2007-2011) and a two-year dementia prediction period (FY2012-2013).

A Large-Scale Genome-wide Association Study of Blood Pressure Accounting for Gene-Depressive Symptomatology Interactions in 564,680 Individuals from Diverse Populations.

Background Gene-environment interactions may enhance our understanding of hypertension. Our previous study highlighted the importance of considering psychosocial factors in gene discovery for blood pressure (BP) but was limited in statistical power and population diversity. To address these challenges, we conducted a multi-population genome-wide association study (GWAS) of BP accounting for gene-depressive symptomatology (DEPR) interactions in a larger and more diverse sample.

The Role of Ginseng and its Bioactive Compounds in Aging: Cells and Animal Studies.

Aging is an inevitable process that is characterized by physiological deterioration and increased vulnerability to stressors. Therefore, the interest in hallmarks, mechanisms, and ways to delay or prevent aging has grown for decades. Natural plant products and their bioactive compounds have been studied as a promising strategy to overcome aging.

Glasgow-Blatchford and Rockall score utility in predicting findings on video capsule endoscopy in patients admitted with overt small bowel bleeding.

Background And Study Aims: Glasgow-Blachford (GBS) and Rockall scores are recognized tools to prioritize patients with upper gastrointestinal bleeding. Their utility in predicting findings on capsule endoscopy (CE) in patients with overt small bowel bleeding (OSBB) remains unclear. The aim was to assess use of these scores in predicting relevant findings on CE and outcome among patients with suspected OSBB.

Tumor-treating fields and concurrent cisplatin: an demonstration of efficacy in triple-negative breast cancer.

Chemotherapy is commonly used to treat patients with triple-negative breast cancer. Combinations of platinum-based chemotherapies have demonstrated higher rates of pathologic complete responses of triple-negative breast cancer compared to combinations without platinum-based chemotherapies. However, there is a significant increase in general toxicity with the addition of platinum-based regimens.