Publications by authors named "J E Ness"
Article Synopsis
- The study investigates how social determinants of health (SDOH) impact pediatric-onset multiple sclerosis (POMS), particularly in terms of adverse SDOH frequency and their effects on treatment and outcomes.
- Researchers conducted a retrospective analysis of data from the United States Network of Pediatric MS Centers, focusing on various demographic and clinical outcomes related to SDOH hardships.
- Findings indicated that 66% of participants faced social hardships, which influenced factors such as age at symptom onset, steroid treatment likelihood, study attrition risk, and overall health scores.
ADEM is an inflammatory disease, with new onset polyfocal neurologic symptoms, encephalopathy and multifocal demyelination, typically in childhood. Initial diagnosis of ADEM is challenging and up to 20 % of children with MS or NMOSD are initially diagnosed with ADEM. We describe characteristics of patients with monophasic ADEM vs.
View Article and Find Full Text PDFBackground: Only 5% of aquaporin-4-positive neuromyelitis optica spectrum disorder (AQP4+ NMOSD) cases emerge during childhood. Poorer outcomes have been suggested in black/African American (AA) adults with NMOSD; however, conflicting and limited data exist for pediatric-onset NMOSD. This study evaluates racial, ethnic, and socioeconomic disparities in pediatric AQP4+ NMOSD outcomes.
View Article and Find Full Text PDFIntroduced species can negatively impact endemic flora and fauna. Studies have primarily utilized camera trap observations and occupancy modelling to better clarify the presence/absence and temporal overlap of endemic and exotic predators. Longitudinal data from field research sites are important as they can provide a finer understanding of predator dynamics and their effects on endemic species.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the effects of IL-11, a member of the IL-6 cytokine family, on retinal angiogenesis, particularly in the context of proliferative diabetic retinopathy (PDR).
- Findings show that IL-11 can have antiangiogenic effects when signaling directly (cis-signaling) and proangiogenic effects when interacting with soluble receptors (trans-signaling).
- In vivo experiments indicated that both forms of signaling reduce retinal neovascularization and activate Müller cells, suggesting IL-11 influences different retinal cell types rather than just vascular endothelial cells.