Publications by authors named "J E Midgley"
Sphingosine phosphate lyase insufficiency syndrome (SPLIS) is a genetic disease associated with renal, endocrine, neurological, skin and immune defects. SPLIS is caused by inactivating mutations in SGPL1, which encodes sphingosine phosphate lyase (SPL). SPL catalyzes the irreversible degradation of the bioactive sphingolipid sphingosine-1-phosphate (S1P), a key regulator of lymphocyte egress.
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- Sphingosine-1-phosphate lyase insufficiency syndrome (SPLIS) is a rare genetic disorder linked to severe health issues like nephrotic syndrome, adrenal insufficiency, and various systemic symptoms, primarily caused by mutations in the SGPL1 gene.
- A study of 76 SPLIS patients found that overall survival is around 50%, with survival influenced by factors such as age at diagnosis, organ involvement, whether the patient received a kidney transplant, and specific SGPL1 genotypes.
- Children diagnosed with SPLIS nephropathy before age one have a significantly worse survival rate compared to those diagnosed after one year, highlighting the importance of early diagnosis and potential interventions.
Pollen transfer efficiency (PTE; the proportion of pollen removed from flowers that reaches conspecific stigmas) is expected to vary with the type of pollinator and flower morphology, and to influence male siring success. Many species in the genus are pollinated by bees (which consume pollen and should thus lower PTE) but during its radiation in the Cape, several independent shifts to both sunbird and long-proboscid fly (LP fly) pollinators, which do not consume pollen have taken place. Improvements in PTE could be one of the factors driving these pollinator shifts.
View Article and Find Full Text PDF(mopane) forms mono-dominant woodlands covering extensive areas of southern Africa. Mopane provides a staple foodstuff for elephants, who hedge woodland by reducing trees to small trees or shrubs, leaving emergent trees which are too large to be pollarded. Emergent trees are important for supporting faunal biodiversity, but they can be killed by ringbarking.
View Article and Find Full Text PDFUnlabelled: Radioiodine treatment (RIT) has a high success rate in both the treatment of hyperthyroidism and improving the quality of life (QoL) of symptomatic patients. In asymptomatic patients with subclinical hyperthyroidism thyroid related QoL outcomes are less well known.
Methods: Study aim was to evaluate thyroid-related QoL in patients with subclinical hyperthyroidism mostly due to toxic nodular goitre undergoing RIT, compared to a control group of euthyroid subjects.