Publications by authors named "J E Mangino"
Article Synopsis
- Nasal carriers were split into two groups to receive either XF-73 nasal gel or a placebo, administered five times over approximately 24 hours before cardiac surgery.
- Patients using XF-73 showed a significant reduction in bacteria levels after two doses, with a decrease of -2.2 log CFU/mL, while the placebo group had almost no reduction at -0.01 log CFU/mL.
- Post-surgery, 46.5% of the XF-73 group required anti-staphylococcal antibiotics compared to 70% in the placebo group, indicating a significant reduction in post-operative antibiotic usage for those treated with XF-73 (p = 0.045).
We studied 83 cardiac-surgery patients with nasal carriage who received 4 intranasal administrations of XF-73 nasal gel or placebo <24 hours before surgery. One hour before surgery, patients exhibited a nasal carriage reduction of 2.5 log with XF-73 compared to 0.
View Article and Find Full Text PDFBackground: Private practice dentists represent 72% of United States dentists. We conducted a prospective cohort study of private practice dentists comparing antibiotic use before and after dental antibiotic stewardship education by infectious diseases (ID) antibiotic stewardship experts.
Methods: Study phases were as follows: phase 1 (preeducation), 3 months of retrospective antibiotic data and a presurvey assessed baseline antibiotic knowledge; phase 2 (education), dentists attended 3 evening Zoom sessions; phase 3, (posteducation/interventions), 3 months of prospective audits with weekly feedback; phase 4, postsurvey and recommendations to reach more dentists.
Background: Overuse of antibiotics from the inpatient to outpatient setting is an antibiotic stewardship initiative where noninfectious disease (ID) pharmacists can have a large impact. Our purpose was to evaluate antibiotic durations across transitions of care from the inpatient to outpatient setting.
Methods: This is a single-center, retrospective cohort analysis evaluating antibiotic durations from the inpatient and outpatient setting in adult patients admitted to general surgery and medicine services at an academic medical center between January 1, 2017 and September 20, 2017.