Publications by authors named "J E Leysen"
The human skin microbiome plays an essential role in protecting against pathogens and other external substances. This open ecosystem is also influenced by personal and environmental factors, but the precise impact of these factors, such as lifestyle and season, is understudied. We focused here on the inner elbow, a skin site prone to inflammatory conditions like atopic dermatitis and psoriasis.
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- * A study using advanced sequencing techniques found that the skin microbiome in mild AD does not significantly differ in diversity from non-AD patients, and the presence of Staphylococcus aureus remains similar in both groups.
- * However, certain bacteria were found in higher or lower abundances in mild AD lesions, suggesting that understanding these differences could lead to new diagnostic tools and treatments to help manage this condition early on.
The role of T cell receptor (TCR) diversity in infectious disease susceptibility is not well understood. We use a systems immunology approach on three cohorts of herpes zoster (HZ) patients and controls to investigate whether TCR diversity against varicella-zoster virus (VZV) influences the risk of HZ. We show that CD4 T cell TCR diversity against VZV glycoprotein E (gE) and immediate early 63 protein (IE63) after 1-week culture is more restricted in HZ patients.
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- * A study analyzed genetic data from UK Biobank patients with shingles, focusing on immune responses and risk factors, uncovering significant links between susceptibility and human leukocyte antigens (HLAs).
- * Key findings indicate that variations in the major histocompatibility complex play a crucial role in developing shingles, alongside increased immune responses related to type I interferon, offering new insights into how VZV reactivation affects the immune system.