Publications by authors named "J E Lea"
Article Synopsis
- PAX2 is identified as an endometrial tumor suppressor frequently inactivated through a unique epigenetic mechanism, rather than promoter hypermethylation.
- In 80% of endometrial cancers, the loss of PAX2 is linked to transcriptional silencing, which alters chromatin features, contributing to cancer development.
- The research highlights new pathways for understanding endometrial cancer origins, potentially influencing future diagnosis and treatment approaches.
Endoplasmic reticulum aminopeptidase 1 (ERAP1) cleaves the -terminal amino acids of peptides, which can then bind onto major histocompatibility class I (MHC-I) molecules for presentation onto the cell surface, driving the activation of adaptive immune responses. In cancer, overtrimming of mature antigenic peptides can reduce cytotoxic T-cell responses, and ERAP1 can generate self-antigenic peptides which contribute to autoimmune cellular responses. Therefore, modulation of ERAP1 activity has potential therapeutic indications for cancer immunotherapy and in autoimmune disease.
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- Flexitarian consumers, along with those who are dairy allergic or vegetarian, are driving the demand for plant-based milk alternatives like ricemilk made from both niche pigmented and aromatic rice varieties.
- Sensory analysis showed that pigmented ricemilks had better bioactive and antioxidant properties compared to nonaromatic varieties, but their color was less accepted until consumers tasted them, especially finding red ricemilk appealing after tasting it.
- Aromatic brown ricemilk emerged as the favorite among consumers for its desirable 'dairy-like' aroma, indicating a strong market potential for ricemilks made from aromatic and whole grain rice varieties as healthier beverage options.
The use of depth of anesthesia monitoring, such as a processed electroencephalogram (pEEG), can decrease the risk of awareness with recall, yet the current standards for monitoring during the administration of anesthesia do not include the use of brain monitoring for anesthetic depth. This retrospective cohort study describes the frequency of use and explores the characteristics of utilization of pEEG monitoring by anesthesia professionals during the administration of general anesthesia in the adult patient population at a large academic medical center. Descriptive associations with pEEG monitoring were confirmed in both univariate and multivariable analyses with multiple patient, anesthetic, and surgical characteristics.
View Article and Find Full Text PDFIntroduction: Mental imagery is a dynamic mental state involving the cognitive visualization and rehearsal of motor movements or positions without overt motor output. Mental imagery is known to have numerous benefits for skill acquisition within athletic performance and is often incorporated into elite athletic training programs. The literature on the effects of mental imagery in surgery, which shares many of the high-performance qualities of elite athletics, remains limited.
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