Publications by authors named "J E Kritchevsky"
Objective: Pergolide, labeled for the treatment of pituitary pars intermedia dysfunction, is 90% protein bound and might cause a decrease in blood thyroid hormone concentrations by displacing them from binding proteins. This study investigated the effect of pergolide on the equine thyroid function.
Methods: This was an analytic, observational, cohort study.
Introduction: Probiotics have been investigated for their many health benefits and impact on the microbiota of the gut. Recent data have also supported a gut-lung axis regarding the bacterial populations (microbiomes) of the two locations; however, little research has been performed to determine the effects of oral probiotics on the microbiome of the bovine respiratory tract. We hypothesized that probiotic treatment would result in changes in the lung microbiome as measured in lung lavage fluid.
View Article and Find Full Text PDFProbiotics have been investigated for many health benefits; however, few studies have been performed to determine the effects of oral probiotics on peripheral blood and respiratory immune cells in cattle. Our objectives were to determine changes in health and growth status, differential blood cell counts and function, and blood and lung cell function using flow cytometry and PCR in dairy calves fed a milk replacer with (PRO, N = 10) or without (CON, N = 10) the addition of probiotics to the milk replacer and dry rations from birth to weaning. Performance and clinical scores were not different between the treatment groups.
View Article and Find Full Text PDFArticle Synopsis
- Equine thyroid disorders are complex to diagnose due to the horse's ability to tolerate fluctuations in thyroid hormone levels and the impact of various nonthyroidal factors on their thyroid axis.
- While benign thyroid tumors are common in older horses, true conditions like hypothyroidism and hyperthyroidism are rare, and there’s a misconception that low thyroid hormone levels in horses indicate hypothyroidism, particularly when linked to symptoms like obesity and poor performance.
- Assessing thyroid function in horses involves measuring hormone levels, but interpretation is tricky, and dynamic tests can aid diagnosis; typically, thyroid hormone supplementation is used more for managing issues like obesity rather than treating true hypothyroidism, which is uncommon.
Article Synopsis
- - The study analyzes 13 horses with a newly identified idiopathic hepatitis syndrome, characterized by symptoms like fever and elevated liver enzyme levels over a period of 16 months.
- - Horses experienced cyclic fevers for about three weeks, with histological findings showing liver damage and inflammation, but none displayed signs of liver failure, and all recovered clinically.
- - While the exact cause remains unknown, the research suggests a seasonal pattern and hints at a possible infectious origin based on the clinical symptoms and histological outcomes.