Publications by authors named "J E Knoefel"
Objective: Hippocampal atrophy is an indicator of emerging dementia in PD, though it is unclear whether cerebral spinal fluid (CSF) Abeta-42, t-tau, or alpha-syn predict hippocampal subfield atrophy in a cohort of PD patients. To examine whether levels of CSF alpha-synuclein (alpha-syn), beta-amyloid 1-42 (Abeta-42) or total-tau (t-tau) are associated with hippocampal subfield volumes over time.
Methods: We identified a subset of Parkinson's Progression Markers Initiative (PPMI) PD patients with longitudinal T1-weighted imaging (baseline plus at least two additional visits across 12, 24, and 48 months) and CSF biomarkers available at baseline.
A trichotomy method for defining homogeneous subgroups in a dementia population.
Ann Clin Transl Neurol
October 2023
Article Synopsis
- The study discusses the challenges of diagnosing mixed dementia, which combines Alzheimer's disease and vascular disease, by developing a new method to identify and classify different patient groups.
- Using cerebrospinal fluid and brain imaging data, the researchers identified eight distinct subgroups, including those with preclinical forms of Alzheimer's and vascular dementia.
- The findings highlight a significant relationship between cognitive functioning and the identified biomarkers, suggesting that further research is necessary to enhance diagnostic approaches.
Blood-brain barrier (BBB) permeability can be measured by the ratio of albumin in cerebrospinal fluid (CSF) and blood and by dynamic contrast-enhanced MRI (DCEMRI). Albumin is a large molecule measured in CSF and blood to form the albumin index (Q), which is a global measure of BBB permeability, while the smaller Gadolinium molecule measures regional transfer (K); few studies have directly compared them in the same patients. We used both methods as part of a study of mechanisms of white matter injury in patients with different forms of dementia.
View Article and Find Full Text PDFIntroduction: Subcortical ischemic vascular disease (SIVD) and Alzheimer's disease (AD) related dementia can coexist in older subjects, leading to mixed dementia (MX). Identification of dementia sub-groups is important for designing proper treatment plans and clinical trials.
Method: An Alzheimer's disease severity (ADS) score and a vascular disease severity (VDS) score are calculated from CSF and MRI biomarkers, respectively.
Persons with dementia (PWD) often experience difficulty navigating their environments and performing out-of-home activities. Life-space mobility (LSM) is an effective way of assessing functional levels and independence. We present a dyadic case study to explore the feasibility of using a global positioning system (GPS) watch to measure LSM of a Latino PWD.
View Article and Find Full Text PDF