Publications by authors named "J E Karp"
High-sensitivity total-body PET enables faster scans, lower doses, and dynamic multiorgan imaging. However, the higher system cost of a scanner with a long axial field of view (AFOV) hinders its wider application. This paper investigates the impact on the lesion quantification and detectability of cost-effective total-body PET sparse designs.
View Article and Find Full Text PDFObjective: To develop age-appropriate nonaGEnaRIan And cenTenarian suRgICal (GERIATRIC) risk tool for classifying patients who may or may not develop postoperative complications or die within their index hospital admission.
Background: There are no validated perioperative risk stratification tools for use in nonagenarian and centenarian patients-people aged 90 to 99 years and >100 years.
Methods: In this retrospective observational study, nonagenarians and centenarians undergoing any surgical procedure were profiled.
In the American Society for Apheresis (ASFA) guidelines, the abbreviation for therapeutic plasma exchange is standardized as TPE. However, the term PLEX (derived from PLasma EXchange), among others, is not infrequently encountered in clinical practice and in publications. Search queries were performed in PubMed using therapeutic plasma exchange, plasma exchange, "therapeutic plasma exchange," "plasma exchange," TPE plasma, PLEX plasma, PEX plasma, TPE, PLEX, and PEX.
View Article and Find Full Text PDFDifficult to Treat Depression: Focus on Approach, Algorithms, and Access.
J Clin Psychiatry
November 2024
Article Synopsis
- The pandemic intensified awareness of depression's impact throughout life, prompting healthcare systems and advocates to prioritize prevention and treatment.
- Efforts continue to tackle the challenge of treating adult patients with difficult-to-treat depression who don’t respond to standard medications, while the psychiatric workforce faces limitations.
- The University of Arizona hosted the Southwest Forum on Difficult to Treat Depression in July 2024, bringing together experts to discuss innovative treatment methods, effective care algorithms, and improving access to depression care.
Article Synopsis
- Major depressive disorder in older adults (late-life depression) often leads to cognitive impairment, particularly in executive function, which may contribute to treatment resistance.
- This study analyzed baseline cognitive data from 369 older participants in a clinical trial to understand the relationship between cognitive deficits and the effectiveness of pharmacotherapy for treatment-resistant late-life depression.
- The findings revealed that participants exhibited significant challenges in inhibitory control and processing speed, with deficits in set shifting specifically predicting poorer response to treatment, indicating a need for tailored therapeutic approaches.