Publications by authors named "J E Jimenez-Salazar"
Purpose: The epithelial-to-mesenchymal transition (EMT) is the main event that favors cell migration and metastasis in breast cancer. Previously, we demonstrated that 1 nM estradiol (E) promotes EMT, induced by c-Src kinase, causing changes in the localization of proteins that compose the tight junction (TJ) and adherens junction (AJ).
Methods: The present work highlights the central role of c-Src in the initiation of metastasis, induced by E, through increasing the ability of MCF-7 and T47-D cells, which express estrogen receptor alpha (ERα), to migrate and invade before they become metastatic.
Estrogens have been implicated in the etiology of breast cancer for a long time. It has been stated that long-term exposure to estrogens is associated with a higher incidence of breast cancer, since estradiol (E) stimulates breast cell growth; however, its effect on DNA damage/repair is only starting to be investigated. Recent studies have documented that estrogens are able to modify the DNA damage response (DDR) and DNA repair mechanisms.
View Article and Find Full Text PDFIn the present study, we investigated the effects of 17β-estradiol (E) on membrane roughness and gold nanoparticle (AuNP) uptake in MCF-7 breast cancer cells. Estrogen receptor (ER)-positive breast cancer cells (MCF-7) were exposed to bare 20 nm AuNPs in the presence and absence of 1×10 M E for different time intervals for up to 24 hrs. The effects of AuNP incorporation and E incubation on the MCF-7 cell surface roughness were measured using atomic force microscopy (AFM).
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- GDF11 is identified as a crucial factor in regulating cell differentiation and has been poorly studied in cancer, especially in hepatocellular carcinoma (HCC), an aggressive liver cancer.
- Treatment with GDF11 reduced the proliferation and colony forming ability of HCC cell lines, altering key cell cycle proteins and indicating compromised cell functionality.
- Additionally, GDF11 treatment led to long-lasting effects on self-renewal capacity and significantly reduced cell migration and proliferation in vivo, suggesting its potential as a tumor suppressor in HCC.
Perfluorooctanoic acid (PFOA) is a member of the perfluoroalkyl acid family of compounds. Due to the presence of strong carbon-fluorine bonds, it is practically nonbiodegradable and highly persistent in the environment. PFOA has been detected in the follicular fluid of women, and positively associated with reduced fecundability and infertility.
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