Publications by authors named "J E J Duysens"
Background: Generalized Joint Hypermobility (GJH) offers flexibility that could enhance motor activities. However, if it leads to injury and pain, it increases functional difficulties and activity limitations. The far-reaching consequences of activity limitations and restricted participation include poor physical fitness and diminished quality of life.
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- - This study analyzed proprioception differences in children aged 8-11 with varying levels of hypermobility, finding no significant differences in proprioception scores between hypermobile and normal mobile groups.
- - Four proprioceptive tests were conducted, including joint position tasks for both upper and lower extremities, with the most accurate position recall occurring at a 90° angle and when estimating wedge height in loaded positions.
- - Results indicated weak correlations between different proprioception tests, suggesting that outcomes for upper extremities do not predict results for lower extremities, and that loading conditions do not affect proprioception based on joint mobility.
Revealing the Therapeutic Potential of Muscle-Derived Mesenchymal Stem/Stromal Cells: An In Vitro Model for Equine Laminitis Based on Activated Neutrophils, Anoxia-Reoxygenation, and Myeloperoxidase.
Animals (Basel)
September 2024
Article Synopsis
- - Laminitis in horses causes severe pain and can lead to euthanasia, prompting research for better treatments through an in vitro model that tests cell responses to stressful conditions.
- - The study found that during reoxygenation, keratinocytes (skin cells) show reduced metabolism, indicating cellular stress, but introducing muscle-derived stem cells helped restore their function.
- - Additionally, exposure to activated neutrophils increased cell activity related to inflammation, which stem cells could help regulate, suggesting their potential use in treating laminitis through cell therapy.
Article Synopsis
- - The study explores the use of equine platelet lysate (ePL) as a replacement for fetal bovine serum (FBS) in growing muscle-derived mesenchymal stromal cells (mdMSCs) for regenerative medicine, addressing ethical and practical issues associated with FBS.
- - Two innovative 2D and 3D culture models were tested, with the 3D model yielding a higher total cell count than the 2D model, while both models confirmed the multipotent capabilities of mdMSCs through differentiation assays.
- - The mdMSCs showed promising immunomodulatory properties, significantly inhibiting myeloperoxidase (MPO) and reactive oxygen species (ROS) activity, especially in the
Background: Generalized Joint hypermobility (GJH) is predominantly non-symptomatic. In fact, individuals with joint flexibility usually perform better than their non-hypermobile counterparts during physical activities. Notwithstanding, strength and balance are essential to maintain the control of the extra range of motion during activities and to prevent musculoskeletal complications.
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