Publications by authors named "J E Higham"

Strong social bonds in gregarious adult animals have been associated with lower levels of glucocorticoids. However, similar research is lacking for juvenile primates. We examined relationships between social bonds and mean concentrations of fecal glucocorticoid metabolites (fGCMs) in 44 free-ranging juvenile rhesus macaques (Macaca mulatta) on Cayo Santiago, Puerto Rico.

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Four-membered heterocycles such as oxetanes and azetidines represent attractive and emergent design options in medicinal chemistry due to their small and polar nature and potential to significantly impact the physiochemical properties of drug molecules. The challenging preparation of these derivatives, especially in a divergent manner, has severely limited their combination with other medicinally and biologically important groups. Consequently, there is a substantial demand for mild and effective synthetic strategies to access new oxetane and azetidine derivatives and molecular scaffolds.

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Tourism has a critical role to play in global carbon emissions pathway. This study estimates the global tourism carbon footprint and identifies the key drivers using environmentally extended input-output modelling. The results indicate that global tourism emissions grew 3.

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Article Synopsis
  • The study investigates how genetic variations that influence gene regulation, specifically through DNA methylation, contribute to differences in traits among rhesus macaques on Cayo Santiago Island, Puerto Rico.
  • Researchers utilized bisulfite sequencing to assess DNA methylation at over 555,000 CpG sites across 573 macaque blood samples, discovering significant genetic effects on methylation levels from single nucleotide polymorphisms (SNPs).
  • Findings revealed that 69.12% of the investigated CpGs had a genetic influence on their methylation (meQTL), which were predominantly located in regions associated with gene expression, highlighting genetic factors that drive phenotypic diversity in these primates.
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Studying biological ageing in animal models can circumvent some of the confounds exhibited by studies of human ageing. Ageing research in non-human primates has provided invaluable insights into human lifespan and healthspan. Yet data on patterns of ageing from wild primates remain relatively scarce, centred around a few populations of catarrhine species.

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