Publications by authors named "J E Hesketh"
Background: Along the southern shoreline of Lake Malawi, the incidence of schistosomiasis is increasing with snails of the genera Bulinus and Biomphalaria transmitting urogenital and intestinal schistosomiasis, respectively. Since the underlying distribution of snails is partially known, often being focal, developing pragmatic spatial models that interpolate snail information across under-sampled regions is required to understand and assess current and future risk of schistosomiasis.
Methods: A secondary geospatial analysis of recently collected malacological and environmental survey data was undertaken.
Article Synopsis
- * Genetic analyses of 76 snail specimens revealed five closely related haplotypes, with only one haplotype being common across different sampled areas, and no variation in microsatellite loci.
- * The prevalence of infected snails in this area was 31%, indicating low genetic diversity among the host snails and suggesting an ongoing local transmission of the schistosomiasis parasite.
Aim: The single-nucleotide polymorphism (SNP) rs713041, located in the regulatory region, is required to incorporate selenium into the selenoprotein glutathione peroxidase 4 (GPX4) and has been found to have functional consequences. This systematic review aimed to conduct a meta-analysis to determine whether there is an association between GPX4 (rs713041) SNP and the risk of diseases in humans and its correlation with selenium status. Material and methods: A systematic search for English-language manuscripts published between January 1990 and November 2022 was carried out using six databases: CINAHL, Cochrane, Medline, PubMed, Scopus and Web of Science.
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- Animal-attached devices have significantly improved our knowledge of vertebrate ecology, but researchers have traditionally assumed that tags should not exceed 3% of the animal's body mass, overlooking the impact of animal movement on tag forces.
- A new method using collar-attached accelerometers on various species reveals that acceptable tag limits should be based on the forces exerted rather than just mass, recommending that tags should produce forces less than 3% of the gravitational force on the animal 95% of the time.
- The study found that tags exceeding the traditional 3% limit can generate forces up to 54% of an animal's body mass during movement, particularly highlighting the need for ethical guidelines to consider the actual impact of tags on animal