Publications by authors named "J E Haarhuis"
In this issue of Molecular Cell, two papers provide insight into atypical structural maintenance of chromosomes protein complexes (SMCs). Jeppsson et al. link Smc5/6 to supercoiled DNA, and Roisné-Hamelin et al.
View Article and Find Full Text PDFCell size varies between cell types but is tightly regulated by cell intrinsic and extrinsic mechanisms. Cell size control is important for cell function, and changes in cell size are frequently observed in cancer. Here, we uncover a role for SETD2 in regulating cell size.
View Article and Find Full Text PDFThere is a growing prevalence of sleep problems and insomnia worldwide, urging the development of new treatments to tackle this increase. Several studies have suggested that the gut microbiome might influence sleep quality. The gut microbiome affects the host's health via the production of metabolites and compounds with neuroactive and immunomodulatory properties, which include short-chain fatty acids, secondary bile acids and neurotransmitters.
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- Cohesin plays a crucial role in structuring the genome by forming chromatin loops and keeping sister chromatids together, with its SMC3 subunit undergoing a dynamic acetylation process influenced by ESCO1 and HDAC8.
- ESCO1 limits the length of chromatin loops and architectural features near CTCF sites, while HDAC8 facilitates their expansion, indicating a complex regulatory mechanism for genome organization.
- The acetylation cycle of cohesin regulates its interaction with PDS5A, acting as a control mechanism that pauses and resumes the growth of chromatin loops, highlighting its importance in the three-dimensional arrangement of the genome.