Clinical Manifestations.

Background: The Clinical Dementia Rating Scale (CDR) is a gold standard metric for staging the nature and severity of global cognitive and functional impairment in Alzheimer's disease (AD) and other dementias. Prior evidence from older and/or smaller samples suggests that The Quick Dementia Rating System (QDRS) informant questionnaire provides results comparable to the CDR and can be completed in just 3-5 minutes, sans a trained clinician or rater. This study aimed to: 1) investigate concordance between the QDRS-derived global CDR ("QDRS-global"; Galvin, 2015) and CDR-global scores; 2) examine item-level QDRS/CDR agreement; and (3) evaluate QDRS-global/CDR-global concordant/discordant groups against concurrent Preclinical Alzheimer's Cognitive Composite (PACC3) performance.

Clinical Manifestations.

Background: Evidence suggests that mindfulness practice may reduce the risk of dementia by enhancing cognitive reserve. However, it's unclear whether APOE ε4 carrier status influences the link between mindfulness and cognitive reserve. This study examined whether associations between mindfulness and memory, language, executive and speed reserve differed by APOE ε4 carrier status.

Clinical Manifestations.

Background: Gait and balance deficiencies may be important indicators of cognitive impairment, distinguishing dementia from normal cognition (NC). It is unclear whether this extends to pre-dementia stages of disease. Study goals were to: assess patterns of mobility across early stages of disease and identify specific measures that distinguish individuals with subjective cognitive impairment (SCI) and mild cognitive impairment (MCI).

Clinical Manifestations.

Background: When performing a picture description task, healthy individuals tend to look only briefly at a target before beginning its description, after which they move promptly onto the next target. This sequence may be disrupted in those with cognitive impairment. Just as cognitively impaired individuals produce greater numbers of disfluencies and pauses, those with mild cognitive impairment (MCI) may delay speech production by extending their gaze behavior towards a target before beginning its description.

Performance of study partner reports in a non-demented at-risk sample.

Introduction: The Clinical Dementia Rating (CDR) Scale is a gold standard for staging impairment in Alzheimer's disease and other dementias (ADRD). The Quick Dementia Rating System (QDRS) offers similar results in 3 to 5 minutes without a trained clinician. This study aimed to (1) investigate concordance between comparably derived QDRS and CDR global scores, (2) examine item-level QDRS/CDR agreement, and (3) compare sample characteristics and cognitive performance across QDRS/CDR global concordant/discordant groups.