Hemolytic uremic syndrome followed by acute lymphocytic leukemia.

A 4 6/12-year-old boy presented with severe hemolytic uremic syndrome (HUS) and then developed acute lymphocytic leukemia (ALL) 8 months later. Although other syndromes of hematopoietic dysfunction have been reported to precede the overt and classic findings of leukemia, this report describes a patient who developed ALL preceded by HUS, association not previously described.

Pulmonary function abnormalities in long-term survivors of childhood cancer.

Pulmonary function testing (PFT) was performed on 29 long-term survivors of childhood cancer. The patients, whose mean age was 11.7 years and whose mean age at diagnosis was 3.

A pharmacokinetic model for predicting the concentration of methotrexate in plasma subsequent to intrathecal injection.

A pharmacokinetic model has been established in which plasma methotrexate (MTX) concentrations following intrathecal administration are predicted. The model is based upon cerebrospinal fluid MTX concentrations following intrathecal injection of MTX, and plasma MTX levels subsequent to i.v.

Probenecid inhibition of methotrexate-cerebrospinal fluid pharmacokinetics in dogs.

Cerebrospinal fluid (CSF) and plasma concentrations of methotrexate (MTX) were followed in dogs for 72 hours after intracisternal injection of MTX with and without probenecid pretreatment. CSF levels declined as a biexponential function of time. Probenecid pretreatment of the animals prolonged the second phase half-disappearance time of MTX from 5.