Altered retinal vasculature in childhood cancer survivors: Data from the German CVSS-study.

Aims: Childhood cancer is a risk factor for cardiovascular diseases in later life. Retinal examination allows to non-invasively observe the vasculature of an end-organ. We observe alterations in long-term childhood cancer survivors (CCS).

An eHealth intervention for patients with a low socioeconomic position during their waiting period preceding cardiac rehabilitation: a randomized feasibility study.

Aims: Cardiac rehabilitation (CR) shows lower effectiveness and higher dropouts among people with a low socioeconomic position (SEP) compared to those with a high SEP. This study evaluated an eHealth intervention aimed at supporting patients with a low SEP during their waiting period preceding CR.

Methods And Results: Participants with a low SEP in their waiting period before CR were randomized into an intervention group, receiving guidance videos, patient narratives, and practical tips, or into a control group.

Enhancing quality of life in individuals with cerebral palsy: a systematic review and meta-analysis of physiotherapy interventions.

Purpose: This systematic review examined studies that addressed physiotherapy intervention approaches to the Quality of Life (QoL) of people with Cerebral Palsy (CP).

Materials And Methods: We conducted a comprehensive search strategy in five databases (PEDro, PubMed, Web of Science, Scopus, and Google Scholar) until 12 February 2024. We assessed the included studies' methodological quality and statistical description using the PEDro scale.

Tuning the mechanical properties of alginate dialdehyde-gelatin (ADA-GEL) bioinks for bioprinting approaches by varying the degree of oxidation.

Extrusion-based 3D bioprinting is one of the most promising and widely used technologies in bioprinting. However, the development of bioprintable, biocompatible bioinks with tailored mechanical and biological properties remains a major challenge in this field. Alginate dialdehyde-gelatin (ADA-GEL) hydrogels face these difficulties and enable to tune the mechanical properties depending on the degree of oxidation (% DO) of ADA.

Inhibition of nitric oxide synthase transforms carotid occlusion-mediated benign oligemia into large cerebral infarction.

It remains unclear why unilateral proximal carotid artery occlusion (UCAO) causes benign oligemia in mice, yet leads to various outcomes (asymptomatic-to-death) in humans. We hypothesized that inhibition of nitric oxide synthase (NOS) both transforms UCAO-mediated oligemia into full infarction and expands pre-existing infarction. Using 900 mice, we i) investigated stroke-related effects of UCAO with/without intraperitoneal administration of the NOS inhibitor (NOSi) N-nitro-L-arginine methyl ester (L-NAME, 400 mg/kg); ii) examined the rescue effect of the NO-donor, molsidomine (200 mg/kg at 30 minutes); and iii) tested the impact of antiplatelet medications.