Publications by authors named "J E Ebersole"
Introduction: Telomeres are nucleotide sequences found at the end of chromosomes, and their shortening is associated with chronological and biological ageing, oxidative stress and malnutrition. Shorter telomeres have been shown to be associated with periodontitis. Dietary nutrients are also influential factors in the aetiology and progression of periodontitis and other chronic inflammatory diseases.
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- Wildfire regimes are altering, raising concerns for aquatic ecosystems and fish species, as predicting fish responses can be complex due to multiple wildfire impacts.
- Whole-ecosystem approaches like food web modeling can help understand these interactions, showing how different wildfire severities affect aquatic life dynamics in streams.
- Simulations reveal that wildfires can have varying effects on periphyton, invertebrates, and fish biomass, influenced by fire severity and environmental changes, indicating a need to consider context when assessing wildfire impacts on aquatic ecosystems.
Type 2 diabetes mellitus (T2DM) is associated with cellular abnormalities, tissue and organ dysfunctions, and periodontitis. This investigation examined the relationship between the oral microbiome and salivary biomarkers in T2DM patients with or without periodontitis. This cohort (35-80 years) included systemically healthy non-periodontitis (NP; n = 31), T2DM without periodontitis (DWoP; n = 32) and T2DM with periodontitis (DWP; n = 29).
View Article and Find Full Text PDFDespite the promising results of immune checkpoint blockade (ICB) therapy, outcomes for patients with brain metastasis (BrM) remain poor. Identifying resistance mechanisms has been hindered by limited access to patient samples and relevant preclinical models. Here, we developed two mouse melanoma BrM models that recapitulate the disparate responses to ICB seen in patients.
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- This study aims to explore the salivary microbiome characteristics in Type 2 diabetes mellitus (T2DM) patients, particularly comparing those with periodontitis to those without it.
- Periodontitis is linked to T2DM, and understanding the differences in oral microbiomes could improve diabetes management and clinical outcomes for patients.
- Results indicated that T2DM patients with periodontitis have distinct microbial profiles and levels of specific salivary analytes, suggesting a unique relationship between oral health and diabetes complications.