Publications by authors named "J E Caughey"
Background: The purpose of this study was to investigate the structure of the incisive canal using dry maxillae harvested from human cadavers.
Methods: Seven dry maxillae were harvested from adult Caucasian human cadavers. The incisive canals in all specimens were observed from an intraoral viewpoint with the naked eye and under a surgical microscope with 20× magnification.
Comprehensive review of the incisive branch of the inferior alveolar nerve.
Anat Cell Biol
December 2021
The incisive branch of the inferior alveolar nerve is a vital anatomical structure within the anterior mandible that has not been thoroughly defined and outlined in reports in the literature until recent years. Advances in radiological imaging, particularly the widespread use of cone-beam computed tomography has allowed for accurate visualization of the mandibular incisive canal (MIC) and its associated incisive branch of the inferior alveolar nerve. Surgical damage to the MIC, which could result in hemorrhage and sensory disturbance, may occur in commonly practiced oral and maxillofacial procedures, such as chin bone harvesting, implant placement, fracture repair and removal of pathologic entities of the anterior mandible.
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- The retinal pigment epithelium (RPE) is crucial for the outer retina, playing key roles in nutrient supply, waste removal, and the retinoid cycle, including daily removal of old photoreceptor disk membranes.
- Impaired degradation of these membranes can lead to harmful lipid accumulation, oxidative damage, and cell death.
- Research using WT and LC3B-deficient mice revealed that RPE peroxisome activity peaks in the morning, suggesting that peroxisome function may be regulated in sync with the daily increase in ingested lipid-rich material.
Objective: The purpose of the study was to explore the impact of dual targeting of C-C motif chemokine receptor-2 (CCR2) and fractalkine receptor (CX3CR1) on the metabolic and inflammatory consequences of obesity induced by a high-fat diet (HFD).
Methods: C57BL/6J wild-type, Cx3cr1 , Ccr2 , and Cx3cr1 Ccr2 double-knockout male and female mice were fed a 45% HFD for up to 25 weeks starting at 12 weeks of age.
Results: All groups gained weight at a similar rate and developed a similar degree of adiposity, hyperglycemia, glucose intolerance, and impairment of insulin sensitivity in response to HFD.