Publications by authors named "J E C Bromberg"
Extracellular vesicles (EVs) transport biomolecules that mediate intercellular communication. We previously showed that EVs contain DNA (EV-DNA) representing the entire genome. However, the mechanism of genomic EV-DNA packaging and its role in cancer remain elusive.
View Article and Find Full Text PDFRegulatory T cells (Tregs) with multifaceted functions suppress anti-tumor immunity by signaling surrounding cells. Here we report Tregs use the surface lymphotoxin (LT)α1β2 to preferentially stimulate LT beta receptor (LTβR) nonclassical NFκB signaling on both tumor cells and lymphatic endothelial cells (LECs) to accelerate tumor growth and metastasis. Selectively targeting LTβR nonclassical NFκB pathway inhibits tumor growth and migration in vitro.
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- The study aimed to analyze the effects of the COVID-19 pandemic on healthcare access and prevalence of health issues among children with autism and children with special health care needs (CSHCN) from 2018 to 2021.
- Findings revealed that around one-third of these children missed preventive care check-ups during the pandemic, with half receiving virtual care in 2021; parents also reported less support for care coordination.
- The research concluded that the pandemic significantly altered healthcare dynamics, highlighting the need for inclusive and adaptable policies to support vulnerable populations in future emergencies.
Article Synopsis
- Fibroblastic reticular cells (FRCs) are crucial for maintaining the structure and function of secondary lymphoid tissues and help modulate immune responses in the lymphoid microenvironment.
- In response to immune challenges like infections or autoimmune diseases, FRCs undergo metabolic reprogramming that alters their functions through the regulation of metabolic pathways and enzymes.
- This review details how FRCs adapt their activities, such as cell growth and cytokine production, to support immune system needs and maintain immune balance under different physiological conditions.
Autoimmune diseases are broadly characterized as a failure in immune tolerance. In multiple sclerosis (MS), autoreactive immune cells attack the protective myelin sheath lining neurons in the central nervous system. Therapeutic strategies that selectively and durably restore immune tolerance without broad immunosuppression are urgently needed for MS.
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