Publications by authors named "J E Brammer"
Article Synopsis
- Researchers are testing valemetostat, an EZH2 and EZH1 inhibitor, for safety and effectiveness in patients with relapsed or refractory non-Hodgkin lymphoma, due to limited treatment options and poor outcomes.
- The study involved 90 participants from 19 hospitals across Japan and the USA, who received varying doses of valemetostat in a phase 1 clinical trial to find the right dosage and assess its anti-tumor effects.
- Initial findings will help determine the most effective dosages and provide insights into the drug's safety profile, with a majority of patients having peripheral T-cell lymphoma.
Maintenance Therapy Post-Stem Cell Transplantation for Patients with T-Cell Lymphomas.
Curr Hematol Malig Rep
December 2024
Article Synopsis
- Post-stem cell transplant (SCT) maintenance therapy is being explored as a way to improve outcomes for patients with peripheral T-cell lymphomas (PTCL), as relapse after SCT is common.
- Recent studies of agents like romidepsin, brentuximab vedotin, duvelisib, and pembrolizumab show promise in reducing relapse rates post-SCT.
- Ongoing trials continue to evaluate the effectiveness of these maintenance therapies, suggesting that they could be a significant strategy in managing PTCL.
Article Synopsis
- FDA-approved treatments ruxolitinib and belumosudil are effective as steroid-sparing agents for chronic GVHD with overall response rates of 76% and 65% respectively.
- A study of 20 patients using a combination of these agents showed a 55% overall response rate, helping patients reduce or stop other immunosuppressants without major complications.
- The combination therapy proved tolerable, did not worsen blood cell counts, and successfully postponed the need for more aggressive treatments.
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