Publications by authors named "J E Boyer"
Cyclic nucleotide GMP-AMP (cGAMP) plays a critical role in mediating the innate immune response through the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway. Recent studies showed that ATP-binding cassette subfamily C member 1 (ABCC1) is a cGAMP exporter. The exported cGAMP can be imported into uninfected cells to stimulate a STING-mediated innate immune response.
View Article and Find Full Text PDFThe Accreditation Council for Pharmacy Education (ACPE) has developed the Accreditation Standards and Key Elements for the Professional Program in Pharmacy Leading to the Doctor of Pharmacy (PharmD) Degree (Standards 2025), effective July 1, 2025. This article describes the processes used to revise the accreditation standards and key elements as well as changes made from Standards 2016 to Standards 2025. Communities of interest were invited to provide written comments via email and/or participate in a web-based survey.
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- Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are liver diseases that damage bile ducts, leading to bile accumulation, liver injury, and increased risk of liver failure; current treatments are limited, especially for PSC.
- Ursodeoxycholic acid is the first-line treatment for PBC, but many patients do not respond fully, indicating a need for better therapies; pruritus (itching) is a common and severe symptom due to cholestasis that is often inadequately treated.
- The review examines the use of PPAR agonists, a type of medication that targets liver metabolism, as potential second-line treatments for PBC and PSC, highlighting recent FDA approvals for
The direct epitaxial growth of high-quality III-V semiconductors on Si is a challenging materials science problem with a number of applications in optoelectronic devices, such as solar cells and on-chip lasers. We report the reduction of dislocation density in GaAs solar cells grown directly on nanopatterned V-groove Si substrates by metal-organic vapor-phase epitaxy. Starting from a template of GaP on V-groove Si, we achieved a low threading dislocation density (TDD) of 3 × 10 cm in the GaAs by performing thermal cycle annealing of the GaAs followed by growth of InGaAs dislocation filter layers.
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- * Patients were referred to PAPT shortly after diagnosis, participated in tailored exercise routines, and maintained regular communication with their physical therapist over a 6-month period.
- * Results showed that patients either met or exceeded exercise guidelines, with significant improvements in physical function and fatigue levels, indicating that the PAPT model is both feasible and effective for improving MS patients' health outcomes.