Publications by authors named "J E Boers"

Article Synopsis
  • The study explores the use of methylated DNA sequencing (MeD-seq) to analyze cell-free DNA (cfDNA) from pregnant women, focusing on detecting unique methylation marks from the placenta during the first trimester.
  • Researchers collected cfDNA from both pregnant and nonpregnant individuals, identifying 436 differentially methylated regions (DMRs) that distinguish pregnant from nonpregnant women, with specific analysis of placental markers.
  • The findings reveal that MeD-seq can effectively identify novel placental-specific methylation patterns in maternal cfDNA, which may also help in determining fetal sex and contribute to understanding pregnancy-related changes in DNA methylation.
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Evaluative conditioning (EC) is a key effect in attitude formation, leading to changes in the liking of neutral attitude objects due to their pairing with positive or negative stimuli. Despite EC's significance, current theories and most empirical findings are limited to stimulus pairings with a single affective stimulus at a time. In contrast, social environments often involve more complex combinations of affective stimuli.

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In patients with proximal hypospadias, often no genetic cause is identified despite extensive genetic testing. Many genes involved in sex development encode transcription factors with strict timing and dosing of the gene products. We hypothesised that there might be recurrent differences in DNA methylation in boys with hypospadias and that these might differ between patients born small versus appropriate for gestational age.

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Two new genera, 17 new species, two epitypes, and six interesting new host and / or geographical records are introduced in this study. New genera include: (based on ) and (based on ). New species include: (from hypersaline sea water, Qatar), (from mycangia of , USA), (on leaves of , Brazil), (from pre-stored , South Africa), (from soil, South Africa), (from dead capsule of , Germany), (from house dust, Canada), (from soil, South Africa), (on ascomata of ascomycete on twigs of , South Africa), (on leaf litter, Spain), (on larva, Thailand), (from soil, South Africa), (from pasture mulch, South Africa), (from soil, South Africa), (on stem, bark of living tree of sp.

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Article Synopsis
  • XIST long noncoding RNA plays a key role in X chromosome inactivation in placental mammals but is present on both X chromosomes in early human embryos without silencing them.
  • XACT lncRNA accumulates alongside XIST on active X chromosomes and may counteract XIST's functions.
  • Research using human embryonic stem cells reveals that XIST modifies chromatin and reduces transcription of X-linked genes, while XACT's absence does not significantly impact XIST’s activity or gene expression, indicating that XIST has a role prior to XCI and highlights a mechanism of temporary X chromosome dosage compensation.
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