Outcomes of Coccidioides Seropositive Solid Organ Transplant Recipients After Self-discontinuation of Antifungal Prophylaxis: The EIA-IgM-only Conundrum.

Background: Solid organ transplant recipients are at risk of severe coccidioidomycosis and are given prophylaxis to mitigate the risk. Patients with seropositive testing typically receive lifelong prophylaxis; currently, this prophylaxis strategy includes patients who are positive only for IgM by enzyme immunoassay (EIA-IgM-only), although this result may be falsely positive.

Methods: We conducted a retrospective study at a large-volume transplant center in an endemic coccidioidomycosis region to compare outcomes of non-lung transplant recipients who were seropositive for Coccidioides but discontinued prophylaxis (case patients) to outcomes of patients who continued prophylaxis (controls).

Symptomatic glucocorticoid-induced adrenal suppression in the United Kingdom and Ireland: a BPSU study.

Objective: To determine the incidence and describe the presentation and management of unexpected symptomatic glucocorticoid-induced adrenal suppression (AS) in children and young people aged 0-15 years.

Setting And Design: Surveillance study of symptomatic glucocorticoid (GC)-induced AS with supportive biochemical evidence or presenting as an adrenal crisis, reported via the British Paediatric Surveillance Unit (BPSU) from September 2020 to September 2022.

Results: Over a 25-month period, 190 reports of symptomatic GC-induced AS/adrenal crisis were made, of which 22 were confirmed cases: 18 AS and 4 adrenal crises.

Nutritional composition, nitrogen-corrected true metabolizable energy, and standardized amino acid digestibility of palm kernel meal from several countries.

Extensive nutritional analyses were conducted for palm kernel meal (PKM) sourced from 5 countries. Two precision-fed rooster trials were conducted to evaluate the nitrogen-corrected true metabolizable energy (TME) and standardized amino acid (AA) digestibility of 10 PKM samples (PKM 1 to 10). The TME was determined using conventional Single Comb White Leghorn roosters, and standardized AA digestibility was determined using cecectomized roosters.

Evaluating the Performance of ChatGPT 3.5 and 4.0 on StatPearls Oculoplastic Surgery Text- and Image-Based Exam Questions.

Introduction: The emergence of large language models (LLMs) has led to significant interest in their potential use as medical assistive tools. Prior investigations have analyzed the overall comparative performance of LLM versions within different ophthalmology subspecialties. However, limited investigations have characterized LLM performance on image-based questions, a recent advance in LLM capabilities.